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The sheep ola major histocompatibility complex compared genic frequencies in normal prealpe sheep and those affected with scrapie



The sheep ola major histocompatibility complex compared genic frequencies in normal prealpe sheep and those affected with scrapie



Comptes Rendus de l'Academie des Sciences Serie III Sciences de la Vie 298(11): 305-308



The OLA genic frequencies were studied in both normal Prealpe sheep and those affected with scrapie. In the non-affected sheep of contaminated flocks, frequencies were generally decreased, compared with frequencies of the same factors in sick sheep or in non-infected controls. Three OLA-A genes significantly decreased; at this locus, results in Prealpe and Ile-de-France sheep were inversed. This observation excludes OLA genes involved in pathogeny or resistance to the disease, but suggests the existence of a linkage between the OLA loci and at least one resistance or susceptibility locus.

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Accession: 006766425

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