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The synthesis of carbon 14 labeled di sodium 3 amino 1 hydroxy propane 1 1 di phosphonate



The synthesis of carbon 14 labeled di sodium 3 amino 1 hydroxy propane 1 1 di phosphonate



Journal of Labelled Compounds & Radiopharmaceuticals 19(10): 1145-1150



Disodium-3-amino-1-hydroxy-1,1-diphosphonate-1-14C (APD 2Na), a powerful Ca binding agent and potential drug for the treatment of Paget's disease, was synthesized. The reaction was carried out by reacting .beta.-alanine (1-14C) with phosphorus acid and phosphorus trichloride in chlorobenzene. Treatment of the resultant ADP with 2 equivalents of NaCH gave the title compound.

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