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The use of 1 alpha hydroxycholecalciferol in the prevention of bovine parturient paresis milk fever

The use of 1 alpha hydroxycholecalciferol in the prevention of bovine parturient paresis milk fever

Israel Journal of Veterinary Medicine 42(4): 85-86; 307-311

ISSN/ISBN: 0334-9152

VetalphaR (350 .mu.g of 1.alpha.-hydroxycholecalciferol in 10 ml propylene glycol) was injected intramuscularly into 10 adult Israeli-Friesian cows. Five of the animals received a second dose four days, and five cows, 5 days after the first. The plasma calcium levels of the injected cows were significantly higher (P < 0.01) than those of the controls from the 2nd until the 14th day after the first injection. Based on these results 568 Israeli-Friesian cows from herds with a milk fever incidence of more than 15% were injected i.m. with VetalphaR near to calving. If parturition had not occurred up to 100 hours later, a second injection was given; parturition was induced 48 hours after the second injection if necessary. There were 43 cases of milk fever among the 568 injected cows (7.6%). Data on 169 cows were reported in days but the best treatment regime was analysed in the 399 cows where data was available inhours. A significantly lower incidence of milk fever (3.1% P < 0.01) was found in 290 of the animals which were injected under the following conditions; 1. more than 24 hours before calving; less than 100 hours between the two injections of VetalphaR-, parturition occurred not more than 100 hours after the injection of Vetalpha (administered once or twice with or without induction of parturition).

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