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Therapeutic and prophylactic effects of taurine administration on experimental liver injury effect of taurine on lipid per oxide formation and calcium content in liver



Therapeutic and prophylactic effects of taurine administration on experimental liver injury effect of taurine on lipid per oxide formation and calcium content in liver



Journal of Kyoto Prefectural University of Medicine 91(1): 9-26



To elucidate possible therapeutic and prophylactic efficacy of taurine (2-aminoethanesulfonic acid) for drug-induced hepatic damages, the effect of taurine administration on hepatic lipid peroxide formation following CCl4 administration was investigated in male Wistar rats. In rats pretreated with taurine (orally 3% aqueous solution for 3 days), the enhancement of lipid peroxidation in the liver was noticed at 24 h after CCl4 (2 ml/kg body wt, i.p.) administration. Taurine had no effect on the metabolism of 14CCl4 in hepatic microsomes or on antioxidant content in the liver. Taurine administration significantly enhanced the CCl4-induced increase in hepatic Ca content. Although CCl4 administration induced a significant increase of non-heme (free) Fe in hepatic microsomes, taurine administration did not modify this increase. Ca2+-stimulated and Fe2+-dependent lipid peroxidation in hepatic microsomes was enhanced by CCl4 treatment, and taurine administration facilitated the Fe2+-dependent lipid peroxidation by increasing Ca2+ content in the liver. Administration of taurine (3 ml 10% aqueous solution at 12, 16 and 20 h after CCl4 administration, using a gastric tube) to rats pretreated with CCl4 showed a significant suppressive effect on CCl4-induced increases in hepatic lipid peroxidation and Ca content. Taurine exhibited differential effects on the increase of hepatic lipid peroxidation induced by CCl4; pretreatment with taurine facilitated hepatic lipid peroxidation; but the administration of taurine following CCl4 treatment suppressed peroxidation. These effects of taurine may be closely related to the alteration of hepatic Ca level induced by this agent.

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