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Therapeutic comparison between ferrous sulfate and trivalent iron in form a polymaltosed ferric hydroxide complex in organic iron deficiency

Schmidt, B.J.; Morais, M.B.; Fisberg, M.; Martins, A.; Machado, N.L.

Folha Medica 90(4): 225-229

1985


ISSN/ISBN: 0015-5454
Accession: 006795723

With the aim to investigate the therapeutic effects of the polymaltosed ferric hydroxide in children with organic iron deficiency, with presence or absence of anemia, the authors developed a double-blind comparative study between the ferric salt and ferrous sulfate and as reference substance. Both were given under the form of syrup undistinguishable in their physics and their taste. Of the total of 30 pre-scholar children of both sexes, 22 finished the 60-day period of therapeutic observation, using a daily oral doses of 4 mg of elementary iron per kg of weight. The two studied groups presented similar demographic, nutritional, clinical, height/weight and laboratory characteristics. The clinical and laboratory assessment of the children was carried out before the beginning of the study and after intervals of 15 days to complete the total treatment period of 2 months. The 12 children (8 boys) treated with trivalent iron were in average 31 months old, 7 were eutrophic and 5 with protein energy deficiency of the first degree under the criteria adopted by Gomez. The controlled group consisted of 10 children (2 boys) with the average age of 33 months, 5 of them were eutrophic and 5 had protein-energy deficiency of the first degree by Gomez. The analysis of the results revealed that both groups achieved the normalization of the altered parameters through the treatment. The assessment of the initial and final results of each group in separate, using the t paired test, revealed a significant increase of ferritin (p < 0.05), Hemoglobin and Iron in serum for both groups. The average increase of weight for the children treated with trivalent iron was slightly higher than the one observed for the controlled group (no significant difference). The tolerability was good for both the substances, however, 30% of the children treated with ferrous sulfate showed darkened spots on their teeth. This fact was not observed in the group treated with trivalent iron.

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