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Thermospray high performance liquid chromatographic mass spectrometric analysis of some fusarium mycotoxins



Thermospray high performance liquid chromatographic mass spectrometric analysis of some fusarium mycotoxins



Journal of High Resolution Chromatography & Chromatography Communications 8(3): 119-125



Thermospray high performance liquid chromatography/mass spectrometry (TSP HPLC/MS) was used to analyze 5 Fusarium mycotoxins in porcine plasma and urine. Four cytotoxic trichothecene mycotoxins, T-2 toxin, HT-2 toxin, diacetoxyscirpenol (DAS), deoxynivalenol (DON), T2 tetraol and the fungal estrogen zearalenone (F-2 toxin) were analyzed. The thermospray mass spectrum contained MW information with few if any, fragment signals. Detection limits ranging from 1 to 10 mg of mycotoxin injected onto the HPLC column were obtained using selected ion monitoring (SIM) HPLC/MS. Neither the plasma nor the urine matrix interfered with TSP HPLC/MS analysis of these mycotoxins and no sample derivatization was necessary for the analysis. The TSP HPLC/MS technique appears to be ideal for very sensitive analysis of mycotoxins in biological samples.

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