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Thiazole derivatives part 1 synthesis and anti inflammatory activity of some 2 alkyl or aryl 2 aryl 4 methyl 4 5 bi thiazolyls and 2 amino substituted amino 2 aryl 4 methyl 4 5 bi thiazolyls



Thiazole derivatives part 1 synthesis and anti inflammatory activity of some 2 alkyl or aryl 2 aryl 4 methyl 4 5 bi thiazolyls and 2 amino substituted amino 2 aryl 4 methyl 4 5 bi thiazolyls



Indian Journal of Chemistry Section B Organic Chemistry Including Medicinal Chemistry 14(7): 552-555



2'-Alkyl- or aryl-2-aryl-4-methyl-4',5-bithiazolyls and 2'-amino- or substituted-amino-2-aryl-4-methyl-4',-5-bithiazolyls were synthesis as potential anti-inflammatory agents by condensing various 2-aryl-5-bromoacetyl-4-methylthiazoles with thioamides and thioureas, respectively. Some compounds showed good activity in the rat. The highest activity was observed in compounds having anisyl groupings.

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