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Tissue distribution of messenger rnas encoding the alpha isoforms and beta subunit of rat sodium potassium atpase



Tissue distribution of messenger rnas encoding the alpha isoforms and beta subunit of rat sodium potassium atpase



Biochemical & Biophysical Research Communications 145(1): 52-58



The tissue distribution of the multiple forms of rat Na+,K+-ATPase was examined at the molecular level with cDNA probes specific for the .alpha., .alpha.(+), .alpha.III and .beta. subunit mRNAs. Northern and slot blot analyses demonstrate that these mRNAs are produced in a tissue-specific manner. RNAs encoding the .alpha.(+) isoform are detected in kidney, brain, heart, adipose, muscle, stomach and lung, whereas .alpha.III RNA is detected in brain, stomach and lung. Both .alpha. and .beta. mRNAs are present in all the tissues studied, although at very different levels. Examination of heart tissue in greater detail demonstrates that the levels of mRNA encoding the .alpha. subunit are greater in the atria than in the ventricles, while the converse is true for .alpha.(+).

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Accession: 006810095

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