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Tissue factor accelerates the activation of coagulation factor viii the role of a bifunctional coagulation cofactor

Tissue factor accelerates the activation of coagulation factor viii the role of a bifunctional coagulation cofactor

Thrombosis Research 40(3): 351-358

One way in which coagulation may be initiated is via the tissue factor pathway in which a non-proteolytic enzyme activator, tissue factor, complexes with a plasma protein, factor VII. Factor VII is the zymogen of the a serine protease, factor VIIa. While factor VII-tissue factor has coagulant activity, upon conversion to factor VIIa the activity increases about 120-fold. We now show that tissue factor markedly accelerates the conversion of factor VII to factor VIIa. Thus, this essential coagulation cofactor is clearly bifunctional.

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Accession: 006810198

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PMID: 4082113

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