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Toxic poly neuropathy due to n hexane a light microscopic and electron microscopic study of the peripheral nerve and muscle from 3 cases



Toxic poly neuropathy due to n hexane a light microscopic and electron microscopic study of the peripheral nerve and muscle from 3 cases



Journal of the Neurological Sciences 47(1): 7-20



Three women developed a predominantly motor polyneuropathy following industrial exposure to an adhesive agent containing 80.4% of n-hexane as a volatile substance. Histological and EM studies were performed on sural nerve and on soleus muscle. In the nerve, there were polymorphous changes in both myelin sheaths and axons of large diameter fibers. Irregular and swollen myelin sheaths and segmental swelling of axons with dissolution of neurotubules and evident increase of neurofilaments were frequently observed. Polymorphous inclusion bodies were often present in Schwann cell cytoplasm. The small myelinated and unmyelinated fibers did not show significant changes. The muscles showed denervation atrophy and focal degenerative myopathic changes, with presence of lymphocytic infiltrates and phagocytosis. This study confirms the noxious effect of n-hexane on the peripheral nerve, with development, in these cases, of a toxic polyneuropathy and denervation muscular atrophy with consistent myopathic changes.

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Accession: 006817289

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