Toxicity of 1 2 di bromo 3 chloro propane 1. histo pathological examination of male rats exposed to 1 2 di bromo 3 chloro propane vapor

Saegusa, J.; Hasegawa, H.; Kawai, K.

Industrial Health 20(4): 315-324

1982


ISSN/ISBN: 0019-8366
Accession: 006817674

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Abstract
The nematocide DBCP [1,2-dibromo-3-chloropropane] causes marked sperm reduction in pesticide workers. A histopathological examination was made of adult male rats which inhaled DBCP. The rats were continuously exposed to 10 ppm DBCP for 14 days and were sacrificed 1, 16 and 36 days, and 12 mo. after exposure. Severe injury was produced in the testicle, kidney and lung. The testicle became completely atrophied with irreversible aspermatogenesis. The renal injury was characterized by proximal tubular necrosis in the outer medulla. In the lung, necrosis and cytomegaly were observed in the bronchial and bronchiolar epithelial cells and the alveolar emphysema. Adult male rats were exposed to 0, 0.3, 1, 3 and 8 ppm DBCP continuously for 14 days. The testicle was examined 1 and 15 days after exposure, revealing pathological changes in the 3 and 8 ppm exposure groups, with recovery and a progressive course, respectively.