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Toxicity of leucaena leucocephala in ruminants the effect of supplemental thyroxine on goats fed on a sole diet of leucaena



Toxicity of leucaena leucocephala in ruminants the effect of supplemental thyroxine on goats fed on a sole diet of leucaena



Australian Journal of Agricultural Research 34(6): 791-798



Daily injections of thyroxine were ineffective in overcoming the toxic effects of feeding Leucaena to goats. The goats did not differ from the controls in live weight change or body condition over the 15 wk of feeding Leucaena and both groups of animals developed esophageal lesions. Treated animals maintained normal serum thyroxine (T4) and triiodothyronine (T3) levels, and did not exhibit the thyroid hyperplasia of the controls. An increase in the serum T4 and T3 levels of 3 controls after 5 wk of feeding was associated with declining mimosine concentration in the feed, and the ability of the hyperplastic thyroids to produce sufficient T4. Serum analyses suggested Zn deficiency in the controls, associated with their low thyroid status. The goitrogenicity of 3-hydroxy-4(1H)-pyridone (DHP) was only partly responsible for the toxicity of Leucaena to ruminants, and the low feed intakes and low live weight gains were related to other effects of DHP. The evidence of extra-ruminal metabolism of DHP was discussed.

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Accession: 006818169

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DOI: 10.1071/ar9830791


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