Section 7
Chapter 6,819

Toxicity studies on metanil yellow in rats

Khanna, S.K.; Srivastava, L.P.; Singh, G.B.

Environmental Research 15(2): 227-231


ISSN/ISBN: 0013-9351
PMID: 668654
DOI: 10.1016/0013-9351(78)90099-3
Accession: 006818666

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Adult male albino rats were kept on diets containing 0.0, 0.1, 0.5 and 3.0% Metanil Yellow [food coloring] for 90 days. Various biochemical and histopathological studies were made. Compared to control animals (0.0%), there was no deviation in food intake and growth rate of Metanil Yellow-fed rats. No pathological change was observed in any of the body organs except the testis. Examination of the testis showed patchy degeneration of seminiferous tubules at a 3.0% dietary level of Metanil Yellow. Leydig cells showed normal appearance. No change was noted in the cholesterol content of the testis nor in the fructose content of the coagulating glands and dorsal prostate. Acid phosphatase activity in the ventral prostate and alkaline phosphatase in the seminal vesicle remained unaffected. Decreases in the activities of testicular hyaluronidase, lactic dehydrogenase and succinic dehydrogenase and in the content of lactic acid were observed.

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