+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Transcriptional regulation of the human prointerleukin 1 beta gene



Transcriptional regulation of the human prointerleukin 1 beta gene



Journal of Immunology 138(11): 3972-3979



Interleukin 1 (IL 1) is a protein produced by monocytes in response to certain antigens which produces a wide variety of cellular responses in various tissues. We have studied the regulation of the human proIL-1 beta gene in THP-1 human monocytic leukemia cells. Lipopolysaccharide (LPS) induction of this gene results in an immediate and transient increase of message that rapidly falls to a low, but constant, level within 6 hr. This decrease results from a specific repression of transcription by 2 hr after stimulation. Cycloheximide inhibition of new protein synthesis causes a superinduction of IL 1 message, but does not alter the initial kinetics of message production. This presumably delays the synthesis of a labile transcriptional repressor protein and implies that the proIL-1 beta gene is under the control of both a transcriptional activator and a newly synthesized transcriptional repressor. The transient increase in mRNA production and the sustained low-level synthesis beyond the initial transient response suggest that the IL 1 protein itself may act intracellularly in a manner analogous to that described for several proto-oncogenes and cellular competence factors.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 006823729

Download citation: RISBibTeXText

PMID: 3495577


Related references

Genomic sequence for human prointerleukin 1 beta: possible evolution from a reverse transcribed prointerleukin 1 alpha gene. Nucleic Acids Research 15(2): 868-868, 1987

Genomic sequence for human prointerleukin 1 beta: possible evolution from a reverse transcribed prointerleukin 1 alpha gene. Nucleic Acids Research 14(20): 7897-7914, 1986

The structure and regulation of the human prointerleukin-1 beta gene. Annales de L'institut Pasteur. Immunology 138(3): 462-469, 1987

Regulation of human prointerleukin 1 beta gene transcription. Lymphokine Research 7(3): 256, 1988

Cloning of complementary dna coding human prointerleukin 1 alpha and prointerleukin 1 beta. Doklady Akademii Nauk SSSR 309(4): 1005-1008, 1989

Cloning and structural analysis of the complementary dna coding for human prointerleukin 1 alpha and prointerleukin 1 beta. Molekulyarnaya Genetika Mikrobiologiya i Virusologiya (12): 13-17, 1989

Cloning and structural analysis of cDNA coding for human prointerleukin-1 alpha and prointerleukin-1 beta. Molekuliarnaia Genetika Mikrobiologiia i Virusologiia 1989(12): 13-17, 1989

Two pathways of human prointerleukin 1 gene regulation. Journal of Cellular Biochemistry Suppl. (11 Part C): 74, 1987

Differential expression of the human prointerleukin 1 beta gene. Cullen, B , Et Al (Ed ) Ucla (University Of California-Los Angeles) Symposia on Molecular And Cellular Biology New Series, Vol 67 Mechanisms Of Control Of Gene Expression; Roche-Ucla Symposium, Steamboat Springs, Colorado, Usa, March 29-April 4, 1987 Xix+376p Alan R Liss, Inc : New York, New York, Usa Illus 125-136, 1988

Human T-cell leukemia virus type I Tax transactivates the promoter of human prointerleukin 1-beta gene through association with two transcription factors, NF-IL6 and Spi-1. Experimental Hematology 25(8): 775, 1997

Cytokine-induced IL-1 beta gene expression in the human polymorphonuclear leukocyte: transcriptional and post-transcriptional regulation by tumor necrosis factor and IL-1. Journal of Immunology 147(8): 2603-2608, 1991

Transcriptional regulation of human thyroid hormone receptor beta 1 gene expression: effect of human retinoid X receptor and identification of a transcriptional silencer region. Molecular and Cellular Endocrinology 110(1-2): 103-112, 1995

Transcription factors NF-IL6 and CREB recognize a common essential site in the human prointerleukin 1 beta gene. Molecular and Cellular Biology 14(11): 7285-7297, 1994

Transcriptional regulation of the beta-7 integrins HML-1 and LPAM-1 Characterization of the human and mouse beta-7 subunit gene promoters. Tissue Antigens 42(4): 246, 1993

Transcriptional repression of the prointerleukin 1b gene by heat shock factor 1. The Journal of Biological Chemistry 271: 874-9, 1996