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Transferable antibiotic resistance in Escherichia coli isolated from urinary-tract infections: hospital v. community patients

Rotimi, V.O.; Emina, P.A.; Eke, P.I.

African Journal of Medicine and Medical Sciences 13(1-2): 47-53

1984


ISSN/ISBN: 0309-3913
PMID: 6087639
Accession: 006825397

To study the prevalence of plasmid-mediated antibiotic resistance in E. coli causing urinary-tract infections (UTI), specimens of urine were obtained from 125 hospital and community patients and examined bacteriologically. Thirty-nine (80%) of 49, and 33 (65%) of 51 hospital and community patients, respectively, were infected by multiple resistant E. coli. Of these multiple-resistant strains > 3/4 carried transferable R-plasmids. Antibiotic resistance was transferred en bloc or singly to known sensitive recipients mainly by conjugation. Resistance markers in both the donor and the recipient strains were eliminated by treatment with aminoacridine dyes and ethidium bromide. The results emphasize the need for bacteriological diagnosis of UTI and sensitivity testing prior to antibiotic therapy.

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