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Translocation of phospholipid calcium dependent protein kinase in b lymphocytes activated by phorbol ester or cross linking of membrane immunoglobulin



Translocation of phospholipid calcium dependent protein kinase in b lymphocytes activated by phorbol ester or cross linking of membrane immunoglobulin



Biochemical Journal 233(1): 145-150



Stimulation of peripheral-blood B-lymphocytes with phorbol ester or anti-immunoglobulin demonstrated intracellular translocation of phospholipid/Ca2+-dependent protein kinase (C-kinase) activity from cytosol to membrane fractions. This phenomenon, which was dose- and time-dependent, was found in both normal and chronic-lymphocytic-leukemia B-cells. This suggests that C-kinase-dependent protein phosphorylation may be related to membrane receptor occupation and may therefore be important in B-lymphocyte responses.

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Accession: 006829297

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