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Trehalose containing lipo oligo saccharides a new class of species specific antigens from mycobacterium kansasii

, : Trehalose containing lipo oligo saccharides a new class of species specific antigens from mycobacterium kansasii. Journal of Biological Chemistry 258(17): 10481-10487

M. kansasii is characterized by the presence of 7 species-specific neutral lipooligosaccharide antigens. All react with hyperimmune anti-M. kansasii serum in enzyme-linked immunosorbent assays and the more glycosylated members also react by gel diffusion. The native glycolipids and their inherent oligosaccharides were purified and the major features of their unique structures determined by acetolysis, partial acid cleavage, 1H-NMR and 13C-NMR, and chemical ionization and electron impact mass spectrometry of the permethylated products. They have in common a tetraglucose core, .beta.-D-Glcp-(1.fwdarw.3)-.beta.-D-Glcp-(1.fwdarw.4)-.alpha.-D-Glcp(1.fwdarw.1)-.alpha.-D-Glcp, where Glcp is glucopyranose, distinguished by the presence of an .alpha.,.alpha.-trehalose substituent. Variable residues of xylose, 3-0-methylrhamnose, fucose and a novel N-acyl aminosugar, (4,6-dideoxy-2-0-methyl-3-C-methyl-4-(2'-methoxypropionamido)hexose; proof of this structure is not given) are linked to the core and the resulting oligosaccharides are acylated with 2,4-dimethyltetradecanoyl and acetyl functions to present a familial arrangement. Related but species-specific lipooligosaccharides typify M. szulgai and apparently a host of other atypical mycobacteria. The antigenicity, and perhaps other features such as pathogenesis and drug resistance, of most atypical mycobacteria may be rationalized in terms of these new found cell wall lipooligosaccharides and the previously described glycopeptidolipids.

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