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Trehalose containing lipo oligo saccharides a new class of species specific antigens from mycobacterium kansasii


, : Trehalose containing lipo oligo saccharides a new class of species specific antigens from mycobacterium kansasii. Journal of Biological Chemistry 258(17): 10481-10487

M. kansasii is characterized by the presence of 7 species-specific neutral lipooligosaccharide antigens. All react with hyperimmune anti-M. kansasii serum in enzyme-linked immunosorbent assays and the more glycosylated members also react by gel diffusion. The native glycolipids and their inherent oligosaccharides were purified and the major features of their unique structures determined by acetolysis, partial acid cleavage, 1H-NMR and 13C-NMR, and chemical ionization and electron impact mass spectrometry of the permethylated products. They have in common a tetraglucose core, .beta.-D-Glcp-(1.fwdarw.3)-.beta.-D-Glcp-(1.fwdarw.4)-.alpha.-D-Glcp(1.fwdarw.1)-.alpha.-D-Glcp, where Glcp is glucopyranose, distinguished by the presence of an .alpha.,.alpha.-trehalose substituent. Variable residues of xylose, 3-0-methylrhamnose, fucose and a novel N-acyl aminosugar, (4,6-dideoxy-2-0-methyl-3-C-methyl-4-(2'-methoxypropionamido)hexose; proof of this structure is not given) are linked to the core and the resulting oligosaccharides are acylated with 2,4-dimethyltetradecanoyl and acetyl functions to present a familial arrangement. Related but species-specific lipooligosaccharides typify M. szulgai and apparently a host of other atypical mycobacteria. The antigenicity, and perhaps other features such as pathogenesis and drug resistance, of most atypical mycobacteria may be rationalized in terms of these new found cell wall lipooligosaccharides and the previously described glycopeptidolipids.

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Frith, C.D., 2006: The value of brain imaging in the study of development and its disorders. Journal of Child Psychology and Psychiatry, and Allied Disciplines 47(10): 979-982

Lecomte, D.; Barres, D.; Durigon, M.; Hadengue, A., 1983: Hepatic histologic lesions in deceased drug addicts. Acta Medicinae Legalis et Socialis 33(1): 819-823

Takano, H.; Takagi, H.; Akutsu, T.; Farish, C.A., 1970: Acute hemodynamic studies of a modified peristaltic bypass type of hear assist device. Journal of Thoracic and Cardiovascular Surgery 60(6): 796-806

Murakami, H.; Tamura, J.; Karasawa, M., 1995: Porphyrias and drugs. The porphyrias are a metabolic disorders of heme biosynthesis characterized by the excessive production and excretion of porphyrins and porphyrin precursors. They are caused by defects in specific enzyme activities and classified into 7 subtypes....

Matsumoto, T.; Fukushima, K.; Motoyama, H.; Higuchi, E.; Ito, Y., 1996: Color flow imaging for direct detection of vesicoureteral and intrarenal reflux. Journal of the American Society of Nephrology 7(9): 1393

Saul S.H.; Novak R.J.; Ross Q.E., 1980: The role of the pre adult stages in the ecological separation of 2 subspecies of aedes aegypti. Two subspecies, differing in behavior and morphology, have evolved in the mosquito species A. aegypti. Both subspecies occupy a wide range of habitats when they are allopatric. In parts of East Africa their distributions overlap and the 2 sspp. oc...

Leggett, Jm, 1983: Chromosome relationships and morphological comparisons in the hybrids Avena hybrida X Avena sativa and Avena hybrida X Avena maroccana Oats. Canadian journal of genetics and cytology = Journal canadien de genetique et de cytologie 25(3): 255-260

Nikitin, S. A., 1978: Prospects for using Ulmus pumila var. arborea in shelter planting. A summary account of the ecology of U. pumila var. arborea with reference to its suitability for use in shelterbelts in the dry regions of the USSR. It is concluded that this elm is promising for use in the difficult conditions of the dry steppe a...

Sindhu, M.A.; Cornfield, A.H., 1968: Effect of simulated reclamations on nitrification of ammonium sulphate applied to saline and alkali soils from West Pakistan. Alkali soil (pH 9.6) and saline-alkali soil (pH 8.5) were treated in the laboratory with CaSO4-containing water, and saline soils (pH 8-8.4) were treated with pure water; the soils were incubated in the presence of (NH4)2SO4 during 12 weeks before...

Jacobi, W.R.; Reich, R.M.; Kallas, M.A., 1997: Relationships of meteorological, soil and site characteristics to the distribution of Armillaria root disease in the Black Hills, SD. Phytopathology 87(6 SUPPL ): S46-S47