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Trends in prescription rates of drugs suspected of inducing hematopoietic disorders in a population in nagoya japan

, : Trends in prescription rates of drugs suspected of inducing hematopoietic disorders in a population in nagoya japan. Nagoya Journal of Medical Science 43(1-2): 29-40

To clarify the frequencies of administration of drugs possibly related to hematopoietic disorders, 3 surveys were conducted during the periods of April-Sept. 1972, Oct. 1975 to March 1976, and Oct. 1977 to March 1978 by reviewing the health insurance receipts for the civil servants in Nagoya. Those who visited medical institutions at least once in a 6-mo. survey period accounted for 71.9, 62.2 and 70.1% among the total civil servants in the 1st, 2nd and 3rd survey, respectively. Among them, relevant drugs were prescribed in 69.2, 68.7 and 50.6%, correspondingly. The prescription rates of chloramphenicols were 13.3, 7.9 and 0.08% in the 1st, 2nd and 3rd survey. The corresponding figures were 1.2, 9.3 and 2.2% for thiamphenicols; 15.3, 9.2 and 12.3% for sulfonamides; and 40.0, 51.5 and 40.9% for antipyretics, analgesics and sedatives. The frequencies of a drug prescribed with other drugs in combination changed over the years. Chloramphenicols were prescribed less frequently with sulfonamides and more frequently with penicillins, cephalosporins and thiamphenicols. The prescription of thiamphenicols with cephalosporins increased over the years. The prescription rates varied according to age in individual drugs. The prescription rates were in general lower in the 20-29 yr age group than in the older age groups in all 3 surveys. Average durations of prescriptions tended to decrease between 1972 and 1977 in sulfanamides, penicillins and cephalosporins.

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