EurekaMag.com logo
+ Site Statistics
References:
48,253,228
Abstracts:
22,798,842
+ Resolve Accession
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
Submit PDF Full TextSubmit PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Treponema pallidum receptor binding proteins interact with fibronectin


, : Treponema pallidum receptor binding proteins interact with fibronectin. Journal of Experimental Medicine 157(6): 1958-1970

Analysis of plasma proteins avidly bound to T. pallidum surfaces revealed the ability of T. pallidum to acquire numerous host macromolecules. No acquisition was evident by the avirulent spirochete, T. phagedenis biotype Reiter. Western blotting technology using hyperimmune antifibronectin serum as a probe revealed the ability of virulent treponemes to avidly bind fibronectin from a complex medium such as plasma. The specificity of the tiplike adherence of motile T. pallidum to fibronectin-coated glass surfaces and to fibronectin on human laryngeal carcinoma HEp-2 cells was reinforced by the observation that pretreatment of coverslips or cell monolayers with monospecific antiserum against fibronectin substantially reduced T. pallidum attachment. The stoichiometric binding of T. pallidum to fibronectin-coated coverslips and the inability of unlabeled or 35S-radiolabeled treponemes to interact with glass surfaces treated with other plasma proteins further established the specific nature of the interaction between virulent T. pallidum and fibronectin. The avid association between 3 outer envelope proteins of T. pallidum and fibronectin was also demonstrated. These treponemal surface proteins have been previously identified as putative receptor-binding proteins responsible for T. pallidum parasitism of host cells. The data suggest that surface fibronectin mediates tip-oriented attachment of T. pallidum to host cells via a receptor-ligand mechanism of recognition.

Order PDF Full Text

Close
Close

Click here to order any other PDF Full Text


Accession: 006839634

PMID: 6304227

DOI: 10.1084/jem.157.6.1958

PDF Full Text: Treponema pallidum receptor binding proteins interact with fibronectin


Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:
Close
Close

Other references

Babineau, K.; Taylor, K.; Clancy, L., 2016: Electronic Cigarette Use among Irish Youth: A Cross Sectional Study of Prevalence and Associated Factors. To examine prevalence of, and factors associated with, e-cigarette use among young people aged 16-17 in Ireland. In 2014, a representative sample of 821 young people aged 16-17 recruited from secondary schools completed a pen and paper survey on e...

Kostera-Pruszczyk, A.; Ryniewicz, B.; Rowinska-Marcinska, K.; Dutkiewicz, M.; Kamińska, A., 2008: Lambert-Eaton myasthenic syndrome in childhood. Lambert-Eaton myasthenic syndrome (LEMS) is a rare autoimmune disorder of the neuromuscular junction. LEMS can be associated with a variety of neoplasms. Patients present with proximal muscle weakness and fatigability, often combined with areflexi...

Tyndall, A.; Gratwohl, A., 2000: Immune ablation and stem-cell therapy in autoimmune disease. Clinical experience. In the past 5 years, around 350 patients have received haematopoietic stem cell (HSC) transplantation for an autoimmune disease, with 275 of these registered in an international data base in Basel under the auspices of the European League Against...

Prichodjko, A.G.; Gabunija, R.I.; Senjukov, M.V.; Matveenko, E.G.; Vtjurin, B.M.; Goldobenko, G.V.; Kudrjavzeva, G.T.; Drozdovskaja, M.I., 1979: Positive tumour scintigraphy. Radiologia Diagnostica 20(1): 86-92

Uyttendaele, H.; Obadiah, J.; Grossman, M., 2003: Dyshidrotic-like spongiotic dermatitis after intravenous immunoglobulin therapy. Intravenous immunoglobulin (IVIG) therapy has been used to treat a variety of immune mediated disorders. Cutaneous reactions to IVIG are rare and have only been anecdotally described. We describe three cases with dyshidrotic-like biopsy proven spo...

O'brien, K.L.; Winkelstein, J.A.; Santosham, M.; Swift, A.; Dover, G.J.; Eskenazi, A.; Luddy, R.E.; Golden, A.S.; Gootenberg, J.; Malinoski, F.J.; Lederman, H.M., 1996: Immunogenicity of a pneumococcal protein conjugate vaccine in infants with sickle cell disease. Pediatric Research 39(4 PART 2): 160A

Ebling, F.J.; Foster, D.L., 1989: Pineal melatonin rhythms and the timing of puberty in mammals. The direction of change in daylength provides the seasonal time cue for the timing of puberty in many mammalian species. The pattern of melatonin secretion from the pineal gland transduces the environmental light-dark cycle into a signal influenci...

Ménard, V.; Girard, H.; Harvey, M.; Pérusse, L.; Guillemette, C., 2009: Analysis of inherited genetic variations at the UGT1 locus in the French-Canadian population. The UDP-glucuronosyltransferase UGT1 locus is composed of nine exon 1s, each flanked by a unique promoter region, and common exons (2, 3, 4, and the alternatively spliced exons 5a and 5b). Here, we characterized the genetic architecture of the UGT...

Hayes, A. H., 1963: A new species of Chaerocina from Abyssinia. Chaerocina ellisoni is described and figured. Only the male is known.

Price, D.K.; Macpherson, G.R.; Dahut, W.; Figg, W.D., 2003: A mutation in COL18A1 and the association with prostate cancer. Proceedings of the American Association for Cancer Research Annual Meeting 44: 810-811, July