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Trh and gonadotropin releasing hormones do not alter levels of oxytocin and oxytocin does not change the response of luteinizing hormone or fsh gonadotropin releasing hormone in humans






Endocrine Research 11(1-2): 75-86

Trh and gonadotropin releasing hormones do not alter levels of oxytocin and oxytocin does not change the response of luteinizing hormone or fsh gonadotropin releasing hormone in humans

Four hundred .mu.g of synthetic TRH were given i.v. to 4 normal men and 4 normal women, and 4 wk later, 1000 .mu.g of TRH were administered i.v. to 4 of the 8 individuals and oxytocin (OT) was measured in plasma on both occasions. Following injection of either dose of TRH, OT did not change significantly from baseline. Likewise, synthetic gonadotropin releasing hormone (GnRH), 100 .mu.g, administered i.v. to 6 normal men did not alter the levels of OT from baseline. Synthetic OT, 300 mU/min, administered 30 min before and for 90 min after injection of GnRH, was without effect on the GnRH-induced rise of luteinizing hormone (LH) or FSH in normal men. Apparently, continuous infusion of OT in pharmacologic concentrations does not alter the pituitary release of LH or FSH in response to GnRH in humans. TRH and GnRH given i.v. do not alter basal levels of OT in the plasma of humans, thus a physiologic role for GnRH or TRH in the neuroendocrine control of OT secretion in humans is unlikely.

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Accession: 006839675



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