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Trh degradation in nih n mouse cerebral and spinal cord

, : Trh degradation in nih n mouse cerebral and spinal cord. Neuroscience Letters 71(2): 209-212

Thyrotropin-releasing hormone (TRH) metabolism in NIH:N mouse cerebral cortex and spinal cord was studied with high pressure liquid chromatography. Degradation of added TRH was significantly (P < 0.001) slower in the spinal cord (2.19 .+-. 0.46% min) than in the cerebral cortex (7.54 .+-. 0.31% min). Bacitracin, a non-competitive inhibitor of TRH deaminidase, inhibited TRH degradation by 61.3 .+-. 3.7% in the spinal cord but only by 35.9 .+-. 1.0% in the cerebral cortex (P < 0.001). Catabolism of TRH in the mouse spinal cord proceeds at a lower rate and predominantly via the TRH deaminidase pathway.

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