EurekaMag.com logo
+ Site Statistics
References:
52,725,316
Abstracts:
28,411,598
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Trh degradation in nih n mouse cerebral and spinal cord


Neuroscience Letters 71(2): 209-212
Trh degradation in nih n mouse cerebral and spinal cord
Thyrotropin-releasing hormone (TRH) metabolism in NIH:N mouse cerebral cortex and spinal cord was studied with high pressure liquid chromatography. Degradation of added TRH was significantly (P < 0.001) slower in the spinal cord (2.19 .+-. 0.46% min) than in the cerebral cortex (7.54 .+-. 0.31% min). Bacitracin, a non-competitive inhibitor of TRH deaminidase, inhibited TRH degradation by 61.3 .+-. 3.7% in the spinal cord but only by 35.9 .+-. 1.0% in the cerebral cortex (P < 0.001). Catabolism of TRH in the mouse spinal cord proceeds at a lower rate and predominantly via the TRH deaminidase pathway.


Accession: 006839707



Related references

Thyrotropin-releasing hormone (TRH) degradation in NIH:N mouse cerebral cortex and spinal cord. Neuroscience Letters 71(2): 209-212, 1986

Experimental investigation on the control of spinal cord circulation part 4 the effect of spinal or cerebral compression on the blood flow of the spinal cord. Acta Neurochirurgica 22(1): 29-41, 1970

Experimental investigation on the control of spinal cord circulation. IV. The effect of spinal or cerebral compression on the blood flow of the spinal cord. Acta Neurochirurgica 22(1): 29-41, 1970

The development of mouse spinal cord in tissue culture part 1 cultures of whole mouse embryos and spinal cord primordia. In Vitro (Rockville) 15(2): 86-94, 1979

The development of mouse spinal cord in tissue culture. I. Cultures of whole mouse embryos and spinal-cord primordia. In Vitro 15(2): 86-94, 1979

Degradation of sendide, a tachykinin NK-1 receptor antagonist, by synaptic membranes of mouse brain and spinal cord. Japanese Journal of Pharmacology 79(SUPPL 1): 220P, 1999

Cerebral activation is correlated to regional atrophy of the spinal cord and functional motor disability in spinal cord injured individuals. Neuroimage 54(2): 1254-1261, 2011

Degradation of nociceptin (orphanin FQ) by mouse spinal cord synaptic membranes is triggered by endopeptidase-24.11: an in vitro and in vivo study. Biochemical Pharmacology 64(8): 1293-1303, 2002

Degradation of nociceptin (orphanin FQ) by mouse spinal cord synaptic membranes is triggered by endopeptidase-24.11: An in vitro and in vivo study. Biochemical Pharmacology 64(8): 1293-1303, 2002

Transplanted astrocytes migrate into host lumbar and cervical spinal cord after implantation of e14 fetal cerebral cortex into adult thoracic spinal cord. Federation Proceedings: 341, 1987