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Trh does not interfere with growth hormone release induced by growth hormone releasing hormone in normal man

, : Trh does not interfere with growth hormone release induced by growth hormone releasing hormone in normal man. Neuroendocrinology Letters 7(6): 289-296

The administration of an i.v. bolus of synthetic hGH-RH (1-40) (0.8/.mu.g/Kg) to 5 normal male volunteers produced a significant plasma GH increase within 10 min, reaching peak values between 30 and 60 min and returning to near basal values in 120 min. This GH releasing effect was not modified by the addition of TRH (i.v. bolus of 400 .mu.g) either given contemporaneously, or 5 min after GH-RH, or as an i.v. 150 min-infusion (1 mg in 400 ml of saline) started 30 min before GH-RH administration. We conclude that neither inhibition nor synergism between GH-RH and TRH in respect to the secretion of GH seem to exist in normal man, in spite of the reports showing that TRH can stimulate or inhibit GH release in some experimental or pathological conditions.

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