+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Trh effects on guinea pig antrum

Gastroenterology 88(5 PART 1): 1126-1131
Trh effects on guinea pig antrum
TRH transiently increased resting tension and spontaneous contraction amplitude more potently in longitudinal muscle than in circular muscle. The frequency of the contraction did not change. Excitation was enhanced by eserine and blocked by atropine and tetrodotoxin; this excitation was probably mediated by acetylcholine release from cholinergic neurons in the myenteric plexus. In the presence of atropine, TRH (10-10 M) inhibited spontaneous contraction, particularly in longitudinal muscle. This was accompanied by decreased resting tension at and above 10-8 M. Because contraction was not blocked by adrenergic blockade, indomethacin, methysergide or hexamethonium, but was abolished by tetrodotoxin, it was postulated that TRH might stimulate nonadrenergic, noncholinergic inhibitory neurons. There was no cross-tachyphylaxis between 5-hydroxytryptamine [5-HT] and TRH 5-HT does not interact with TRH.

Accession: 006839715

Related references

The effects of trh on motility of the guinea pig antrum. Japanese Journal of Smooth Muscle Research 21(SUPPL): 41-46, 1985

Effects of bombesin on contractile motility of the guinea pig antrum. Gastroenterology 88(5 PART 2): 1437, 1985

Thyrotropin-releasing hormone effects on guinea pig antrum. Gastroenterology 88(5 Pt 1): 1126-1131, 1985

Effects of vanadate on the potassium contracture of guinea pig pyloric antrum. Chung-Ang Journal of Medicine 13(3): 331-340, 1988

The effects of thyrotropin releasing hormone on motility of the guinea pig antrum. Nihon Heikatsukin Gakkai Zasshi 21 Suppl: 41-45, 1985

Effects of vanadate and genistein on circular muscles of guinea-pig gastric antrum. Japanese Journal of Physiology 44(SUPPL 1): S138, 1994

Opposite effects of 5-HT on guinea-pig gastric circular muscle strips in antrum and corpus. Gastroenterology 106(4 SUPPL ): A577, 1994

Effects of removal of Na+ and Cl- on the slow wave in the circular muscle of the guinea-pig gastric antrum. Journal of Muscle Research & Cell Motility 21(2): 201-202, February, 2000

Effects of cyclic AMP-related agents on circular muscle of guinea-pig gastric antrum. Japanese Journal of Physiology 44(SUPPL 1): S131, 1994

Effects of dopamine on the contractility of the circular muscles in the guinea pig gastric antrum and fundus. Seoul Journal of Medicine 32(4): 199-207, 1991