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Trh effects on guinea pig antrum

, : Trh effects on guinea pig antrum. Gastroenterology 88(5 PART 1): 1126-1131

TRH transiently increased resting tension and spontaneous contraction amplitude more potently in longitudinal muscle than in circular muscle. The frequency of the contraction did not change. Excitation was enhanced by eserine and blocked by atropine and tetrodotoxin; this excitation was probably mediated by acetylcholine release from cholinergic neurons in the myenteric plexus. In the presence of atropine, TRH (10-10 M) inhibited spontaneous contraction, particularly in longitudinal muscle. This was accompanied by decreased resting tension at and above 10-8 M. Because contraction was not blocked by adrenergic blockade, indomethacin, methysergide or hexamethonium, but was abolished by tetrodotoxin, it was postulated that TRH might stimulate nonadrenergic, noncholinergic inhibitory neurons. There was no cross-tachyphylaxis between 5-hydroxytryptamine [5-HT] and TRH 5-HT does not interact with TRH.

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