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Trh immuno reactivity in the gastro intestinal tract of man


, : Trh immuno reactivity in the gastro intestinal tract of man. Journal of Clinical Endocrinology & Metabolism 56(3): 524-529

TRH inhibits gastric secretion, gastric motility and pancreatic enzyme secretion in man. TRH immunoreactivity (TRH-IR) was measured in mucosal and transmural biopsies from different parts of the stomach, pylorus, duodenum and pancreas in patients undergoing surgery or gastroscopy. TRH-IR was found in pancreas (range, 1.64-3.27 pg TRH/mg protein) and in mucosa of the fundus (13.3 .+-. 2.0 pg TRH/mg protein), antrum (22.5 .+-. 4.5 pg TRH/mg protein), and duodenum (35.5 .+-. 6.4 mg TRH/mg protein). Low levels of TRH-IR were found in transmural biopsies from fundus, antrum and pylorus (range, 0.45-0.87 pg TRH/mg protein). Chromatography of gastrointestinal tissue extracts on a cation exchange column resulted in 2 different TRH-IR peaks, one eluted at pH 3.5 and the other eluted at pH 7.4. The peak at pH 7.4 corresponded to synthetic TRH. The presence and the action of TRH in human gut indicate a physiological role of TRH in the gastrointestinal tract in man.

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