EurekaMag.com logo
+ Translate

Trh immunoreactive neurons project from the ventral medulla to the intermediolateral cell column partial coexistence with serotonin


, : Trh immunoreactive neurons project from the ventral medulla to the intermediolateral cell column partial coexistence with serotonin. Brain Research 381(1): 1-7

Projections from medullary thyrotropin-releasing hormone (TRH) containing neurons to the intermediolateral cell column (IML) of the thoracic spinal cord were studied in the rat. Lesions of the ventral medullary reticular formation nuclei, nucleus paragigantocellularis lateralis and nucleus interfascicularis hypoglossi, decreased the thyrotropin-releasing hormone immunoreactivity in the IML. The ventral horn and dorsal horn contents of TRH were also reduced in rats with nucleus paragigantocellularis lateralis lesions. Coexistence of spinal cord TRH and serotonin was evaluated and quantified in 5,7-dihydroxytryptamne-treated rats. Treatment with the serotonin neurotoxin reduced the TRH content of the IML by 45% and of the ventral horn by 92%. These data show that TRH containing neurons project from the ventral medulla to IML and that approximately one-half of these TRH neurons are also serotonergic. Comparisons of the effects of the same lesions on the substance P and TRH content of the IML show that neither the origin of the SP and TRH neuronal projections to the IML, nor their coexistence with serotonin, are identical.

(PDF 0-2 workdays service)

Accession: 006839723

Submit PDF Full Text: Here


Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:
Close
Close

Related references

Helke, C.J.; Sayson, S.C.; Keeler, J.R.; Charlton, C.G., 1986: Thyrotropin-releasing hormone-immunoreactive neurons project from the ventral medulla to the intermediolateral cell column: partial coexistence with serotonin. Projections from medullary thyrotropin-releasing hormone (TRH) containing neurons to the intermediolateral cell column (IML) of the thoracic spinal cord were studied in the rat. Lesions of the ventral medullary reticular formation nuclei, nucleus...

Helke, C.J.; Neil, J.J.; Massari, V.J.; Loewy, A.D., 1982: Substance P neurons project from the ventral medulla to the intermediolateral cell column and ventral horn in the rat. The descending substance P projections from the ventral medulla were studied in the rat. Electrolytic lesions which included the nucleus interfascicularis hypoglossi decreased the substance P-like immunoreactivity (SP-I) in both the intermediolate...

Sasek C.; Helke C., 1989: Differential coexistence of substance p sp immunoreactivity ir with other neurochemicals in intermediolateral cell column iml projecting neurons in the ventral medulla oblongata vm. Society for Neuroscience Abstracts 15(1): 263

Sasek C.; Haxhiu M.; Helke C., 1990: Relationship of immunoreactive neurokinin a and substance p in ventral medullary neurons that project to the intermediolateral cell column iml and in iml fibers. Society for Neuroscience Abstracts 16(1): 519

Sasek C.A.; Wessendorf M.W.; Helke C.J., 1990: Evidence for co existence of trh substance p and serotonin in ventral medullary neurons that project to the intermediolateral cell column in the rat. The present study was conducted to determine if substance P-, thyrotropin-releasing hormone-and/or serotonin-immunoreactivities coexist in ventral medullary neurons that project to the intermediolateral cell column in the rat. Neurons that project...

Helke, C.J.; Capuano, S.; Tran, N.; Zhuo, H., 1996: Immunocytochemical studies of 5-HT-1A receptor in ventral medullary neurons which project to the intermediolateral cell column , and contain serotonin-ir or tyrosine-hydroxylase-ir. FASEB Journal 10(3): A410

Charlton C.G.; Helke C.J., 1986: Retrograde transport of rhodamine labeled latex microspheres and immunohistochemistry delineate substance p containing neurons in the ventral medulla that project to the intermediolateral cell column. Society for Neuroscience Abstracts 12(1): 301

Helke, C.J.; Capuano, S.; Tran, N.; Zhuo, H., 1997: Immunocytochemical studies of the 5-HT-1A receptor in ventral medullary neurons that project to the intermediolateral cell column and contain serotonin or tyrosine hydroxylase immunoreactivity. Activation of serotonin-1A receptors (5-HT(1A)R) in the medulla oblongata lowers sympathetic nerve discharge and blood pressure. Binding sites for 5-HT(1A)R ligands are present in ventral medullary nuclei [e.g., rostral ventrolateral medulla (RVLM...

Sasek, C.A.; Wessendorf, M.W.; Helke, C.J., 1990: Evidence for co-existence of thyrotropin-releasing hormone, substance P and serotonin in ventral medullary neurons that project to the intermediolateral cell column in the rat. The present study was conducted to determine if substance P-, thyrotropin-releasing hormone- and/or serotonin-immunoreactivities coexist in ventral medullary neurons that project to the intermediolateral cell column in the rat. Neurons that projec...

Sasek, C.A.; Helke, C.J., 1989: Enkephalin-immunoreactive neuronal projections from the medulla oblongata to the intermediolateral cell column: relationship to substance P-immunoreactive neurons. The present study investigated the ventral medullary distribution of enkephalin-immunoreactive neurons that project to the intermediolateral cell column and the relationship of these neurons to substance P-immunoreactive neurons. Neurons that proj...