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Trh improves blood pressure and survival in endo toxic shock

, : Trh improves blood pressure and survival in endo toxic shock. European Journal of Pharmacology 74(1): 101-106

In conscious rats subjected to endotoxic shock, TRH causes a rapid increase in cardiovascular variables and respiratory rates at i.v. doses 0.20-6.34 mg/kg. These doses of TRH significantly improve survival following endotoxemia. The absence of an effect of TRH upon analgesic latencies, combined with its demonstrated efficacy in reversing shock, suggest that it may have therapeutic advantages over the opiate antagonist naloxone.

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