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Trh improves blood pressure and survival in endo toxic shock


European Journal of Pharmacology 74(1): 101-106
Trh improves blood pressure and survival in endo toxic shock
In conscious rats subjected to endotoxic shock, TRH causes a rapid increase in cardiovascular variables and respiratory rates at i.v. doses 0.20-6.34 mg/kg. These doses of TRH significantly improve survival following endotoxemia. The absence of an effect of TRH upon analgesic latencies, combined with its demonstrated efficacy in reversing shock, suggest that it may have therapeutic advantages over the opiate antagonist naloxone.


Accession: 006839726



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