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Trh in experimental spinal injury dose response and late treatment


, : Trh in experimental spinal injury dose response and late treatment. Neurology 10(10): 1280-1284

Early treatment with TRH at high doses improves neurologic recovery from experimental spinal injury in cats. The effects of TRH dose and time of treatment on neurologic outcome were compared. TRH-treated animals showed better motor recovery than saline controls; effects were dose-related (between 0.02 mg/kg/h and 2.0 mg/kg/h), with significant effects even at the lowest dose. Cats treated 24 h after injury also improved significantly. Additional support is provided for TRH trials in human spinal injury and even late treatment may be effective.

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