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Trh induced hyper thermia in mice possible involvement of adrenal and pituitary glands

, : Trh induced hyper thermia in mice possible involvement of adrenal and pituitary glands. British Journal of Pharmacology 80(2): 229-234

To investigate the hyperthermic effect of TRH and its potentiation by exogenous catecholamines (CA), the role of the adrenal medulla and of the pituitary gland was studied in unoperated, adrenal-demedullated or hypophysectomized mice. In unoperated mice, TRH 40 mg kg-1 i.p. produced a hyperthermia which was accompanied by an increase in plasma noradrenaline (norepinephrine, NA) and adrenaline (epinephrine, Ad). NA or Ad, both at a dose of 1 mg kg-1 i.p., enhanced the TRH-induced hyperthermia. Adrenal demedullation suppressed the hyperthermia and the increase of plasma CA produced by TRH but not the potentiation of this hyperthermia by exogenous CA. Hypophysectomy abolished the TRH-induced hyperthermia but not the increase of plasma CA or the potentiation of this hyperthermia by exogenous CA. In mice, evidently both the adrenal medulla and the pituitary gland play an essential role in TRH-induced hyperthermia but not in its potentiation.

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