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Trh induces growth hormone secretion in adult hypothyroid fowl


, : Trh induces growth hormone secretion in adult hypothyroid fowl. General & Comparative Endocrinology 69(2): 233-237

While thyrotrophin-releasing hormone (TRH) stimulated growth hormone (GH) secretion in adult anesthetized cockerels, the GH response was blocked in anesthetized birds pretreated with thyroxine (T4) or triiodothyronine (T3). Moreover, whereas GH secretion in conscious adult birds was poorly responsive to TRH stimulation, conscious birds made hypothyroid by goitrogen pretreatment (with propylthiouracil, methimazole, or thiourea) were responsive to TRH challenge. Basal circulating GH concentrations in the goitrogen-pretreated birds were also higher than in the vehicle-injected controls. Surgical thyroidectomy similarly increased the basal GH concentration in adult birds and promoted TRH-induced GH secretion. These results demonstrate inhibitory effects of the thyroid hormones on basal and stimulate GH secretion in adult domestic fowl and suggest that GH release in adults is partly under tonic thyroidal inhibition.

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Harvey, S.; Scanes, C.G.; Klandorf, H., 1988: Thyrotrophin-releasing hormone induces growth hormone secretion in adult hypothyroid fowl. While thyrotrophin-releasing hormone (TRH) stimulated growth hormone (GH) secretion in adult anesthetized cockerels, the GH response was blocked in anesthetized birds pretreated with thyroxine (T4) or triiodothyronine (T3). Moreover, whereas GH se...

Harvey S.; Scanes C.G.; Klandorf H., 1987: Trh induced growth hormone gh secretion in adult hypothyroid fowl evidence for tonic thyroidal inhibition of gh release. Journal of Endocrinological Investigation 10(SUPPL 3): 22

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Harvey, S.; Sterling, R.J.; Phillips, J.G., 1981: Diminution of thyrotrophin releasing hormone-induced growth hormone secretion in adult domestic fowl (Gallus domesticus). Age-related changes in the response of GH to administration of thyrotrophin releasing hormone (TRH) in fowl were investigated. In two strains of chicken the administration of TRH (10 mu g/kg i/v) to 4-week-old male and female birds markedly increa...

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Harvey S.; Sterling R.J.; Phillips J.G., 1981: Diminution of trh induced growth hormone secretion in adult domestic fowl gallus domesticus. Age-related changes in the response of GH [growth hormone] to administration of TRH were investigated in the domestic fowl. In 2 strains of chicken, the i.v. administration of TRH (10 .mu.g/kg) to 4 wk old male and female birds markedly increased...

Chen, J.; Ortmeier, S.B.; Savinova, O.V.; Nareddy, V.B.; Beyer, A.J.; Wang, D.; Gerdes, A.Martin., 2014: Thyroid hormone induces sprouting angiogenesis in adult heart of hypothyroid mice through the PDGF-Akt pathway. Study of physiological angiogenesis and associated signalling mechanisms in adult heart has been limited by the lack of a robust animal model. We investigated thyroid hormone-induced sprouting angiogenesis and the underlying mechanism. Hypothyroid...

Silva, F.Goulart.da.; Giannocco, G.; Santos, M.Fagundes.; Nunes, M.Tereza., 2006: Thyroid hormone induction of actin polymerization in somatotrophs of hypothyroid rats: potential repercussions in growth hormone synthesis and secretion. Thyroid hormone was shown to induce actin cytoskeleton polymerization in hypothyroid astrocytes and osteoblastic cells by a nongenomic mechanism. Polyadenylation of GH mRNA, a process that depends on cytoskeleton-associated proteins, was also show...

Harvey, S.; Scanes, C.G.; Phillips, J.G., 1985: Growth hormone secretion in anesthetized fowl 1. refractoriness to repeated stimulation by human pancreatic growth hormone releasing factor or trh. The i.v. administration of TRH (1.0 or 10.0 .mu.g/kg) or human pancreatic growth hormone-releasing factor (hpGRF(1-44)NH2, at 10 .mu.g/kg) markedly decreased the growth hormone (GH) concentration in the plasma of immature or adult cockerels anesth...

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