+ Translate

Trh medullary site of action to induce gastric ulcers and stimulate acid secretion

, : Trh medullary site of action to induce gastric ulcers and stimulate acid secretion. Brain Research 459(1): 148-152

This study evaluated the hypothesis that the dorsal motor nucleus (DMN) of the brainstem may mediate the ulcerogenic and acid-stimulatory effects of thyrotropin-releasing hormone (TRH) in rats. To accomplish this, intra-DMN microinjections of TRH (50 and 500 ng) were performed and their effects on acid secretion and gastric ulcer formation evaluated in the pylorus-ligation model. The high (500 ng), but not the low dose of TRH (50 ng) produced gastric glandular lesions in 64% of the rats with a mean severity index (no. of ulcers/rat) of 6.4 .+-. 0.98 and significantly increased gastric acid output. The ulcerogenic and gastric secretory response to intra-DMN TRH was site-specific. We conclude that presynaptic TRH fibers may modulate vagal activity at the level of the DMN and propose that descending TRH pathways may play a role in experimental ulcerogenesis through acid hypersecretion.

(PDF 0-2 workdays service)

Order PDF Full Text


Click here to order any other PDF Full Text

Accession: 006839768

PDF Full Text: Submit

Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:

Other references

Ganesan, T.; Cyril, P. K., 2000: Mycotoxic volatile compounds of plant origin-II. The presence of chromosomal aberrations and behaviour during cell division in Sagittaria sagittifolia grown under stress of chakia sugar mill effluent for a prolonged period. Chromosome abnormalities were higher during metaphase compared to anapha...

Cheng, Tc, 1974: A transmission and scanning electron microscopical study of the rectal ridge of Biomphalaria glabrata (Mollusca: Pulmonata). Cell Tissue. Res54(1): 29-38

Otsuji, N.; Murayama, I., 1972: Dna damage by mono functional mitomycins and its repair in escherichia coli. Journal of Bacteriology 109(2): 475-483

Vogellehner, D., 1982: Botanical illustration in science and art. Berichte der Deutschen Botanischen Gesellschaft5(3): 541-546

Coffey, M. P.; Simm, G.; Hill, W. G.; Brotherstone, S., 2003: Genetic evaluations of dairy bulls for daughter energy balance profiles using linear type scores and body condition score analysed using random regression. The difference in body lipid between the start and end of lactation represents the body energy lost (or gained) in support of maintaining lactation including the nonproduction components of lactation. This source of energy is ignored in current ge...

Russo, J.; Russo, I. H., 1997: Role of hormones in human breast development The menopausal breast. Maturitas 27(SUPPL ): 5

Meissner, John D., 1999: Nucleotide sequences and further characterization of human papillomavirus DNA present in the CaSki, SiHa and HeLa cervical carcinoma cell lines. The complete nucleotide sequences of the human papillomavirus type 16 (HPV-16) variants present in the CaSki and SiHa cervical carcinoma cell lines and the primary subgenomic HPV-18 variant present in the HeLa cervical carcinoma cell line were det...

Wolf G., 1983: The concentrated autologous tissue glue. Since 1980 an autologous tissue glue has been used for microsurgery and plastic surgery in otorhinolaryngology. This tissue glue is made from the patient's own blood plasma. Advantages are no danger of an immune reaction or infection by virus...

Kamakura, Yayoi; Hasegawa, Mitsuhiro; Minamoto, Toshinari; Yamashita, Junkoh; Fujisawa, Hironori, 2006: C-kit gene mutation: common and widely distributed in intracranial germinomas. Object. Of the intracranial germ cell tumors (IGCTs), 10% of germinomas and most nongerminomatous tumors remain refractory to multimodality therapy. The authors investigated the mutation of e-kit and the expression of its product KIT in IGCTs to i...

Reinecke, JP., 1981: Sexing living pupae and teneral adults of a sunflower stem weevil, Cylindrocopturus adspersus. The author reports that Cylindrocopturus adspersus (Lec.), an important pest of sunflower in the USA, can be sexed during the melanisation period of the pharate adult and a few hours after emergence. The wishbone-shaped spiculum ventrale of the 8t...