EurekaMag.com logo
+ Translate

Trh responsiveness and degradation in children with chronic renal failure effect of time of evolution


, : Trh responsiveness and degradation in children with chronic renal failure effect of time of evolution. Acta Endocrinologica 99(4): 508-516

In order to study the hypothalamic-pituitary-thyroid function in children with chronic renal failure (CRF), the serum levels of L-thyroxine (L-T4), L-triiodothyronine (L-T3), reverse T3 (rT3), TSH and prolactin (Prl) were measured by radioimmunoassay. Values were compared with those of normal subjects. Low levels of L-T4 were present in CRF patients as compared to controls. L-T3 was also low but less than L-T4, and rT3 was lower in patients with long evolution. No alterations were observed in TSH basal levels, whereas Prl values in patients were high. After TRH administration, TSH and Prl rose to similar levels in both groups, but high values were maintained throughout (120 min) in CRF. A significant negative correlation was found between the peak rise of the TSH response and the CRF evolution time. The L-T3 response to TRH administration (120 min) was similar in both CRF and controls. The rate of in vivo and in vitro exogenous TRH degradation was decreased in patients with CRF or by their sera, respectively. Apparently the hypothyroid syndrome described in CRF patients is of hypothalamic origin, and the low in vivo and in vitro TRH degradation rates are a consequence of this state.

(PDF 0-2 workdays service)

Accession: 006839795

Submit PDF Full Text: Here


Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:
Close
Close

Related references

Henneberg, C.M.; Domenech, J.M.; Montoya, E., 1982: Thyrotrophin-releasing hormone responsiveness and degradation in children with chronic renal failure: effect of time of evolution. In order to study the hypothalamic-pituitary-thyroid function in children with chronic renal failure (CRF), the serum levels of L-thyroxine (L-T4), L-triiodothyronine (L-T3), reverse T3 (rT3), thyrotrophin (TSH) and prolactin (Prl) were measured b...

Lewin I.G.; Hendy G.N.; Papapoulos S.E.; Tomlinson S.; O'riordan J.L.H., 1985: Effect of renal function on renal responsiveness to parathyroid hormone in primary hyperparathyroidism and chronic renal failure. The effect of renal function on the cyclic AMP (cAMP) response to exogenous parathyroid hormone (PTH) was examined in patients with chronic renal failure (n = 22) and primary hyperparathyroidism (n =19). In the patients with chronic renal failure...

Manca, F.; Perfumo, F.; Kunkl, A.; Costantini, M.; Gusmano, R., 1989: In vitro evidence for impaired cellular immune responsiveness in children with chronic renal failure. We used mixed lymphocyte culture (MLC) as an assay to evaluate in vitro the cellular immune functions of children with chronic renal insufficiency (CRI) or with chronic renal failure (CRF). The proliferative response of lymphocytes from both group...

Sato, N.; Mukai, T.; Furuichi, A.; Esumi, K.; Ohtsuka, M.; Shimomura, K., 1995: Effect of enalapril on renal vascular responsiveness to angiotensin II and bradykinin in rats with partial ablation-induced chronic renal failure. Japanese Journal of Pharmacology 67(SUPPL 1): 317P

Schaefer, F.; Wingen, A.M.; Hennicke, M.; Rigden, S.; Mehls, O., 1996: Growth charts for prepubertal children with chronic renal failure due to congenital renal disorders. European Study Group for Nutritional Treatment of Chronic Renal Failure in Childhood. Despite the high prevalence of and therapeutic attention to growth failure in children with chronic renal failure (CRF), systematic evaluations of spontaneous growth in CRF are lacking. Therefore, we collected retrospectively longitudinal growth a...

Marti Henneberg C.; Montoya E., 1978: Lower serum thyrotropin releasing hormone degradation in chronic renal failure in children. Pediatric Research 12(2): 163

Oste, L.; Bervoets, A.R.; Behets, G.J.; Dams, G.; Marijnissen, R.L.; Geryl, H.; Lamberts, L.V.; Verberckmoes, S.C.; Van Hoof, V.O.; D.B.oe, M.E.; D'Haese, P.C., 2005: Time-evolution and reversibility of strontium-induced osteomalacia in chronic renal failure rats. Background. Patients with impaired renal function can accumulate strontium in the bone, which has been associated with the development of osteomalacia. A causal role for strontium in the development of the disease was presented in chronic renal fa...

Pistor, K.; Schärer, K.; Olbing, H.; Tamminen-Möbius, T., 1985: Children with chronic renal failure in the Federal Republic of Germany: II. Primary renal diseases, age and intervals from early renal failure to renal death. Arbeitsgemeinschaft für Pädiatrische Nephrologie. In a retrospective survey, 623 children with chronic renal failure (CRF) comprising a 7-year period were registered in the Federal Republic of Germany. The primary renal disease could be classified in 91% of the patients. Pyelonephritis was the mo...

Pistor, K.; Scharer, K.; Olbing, H.; Tamminen-Mobius, T., 1985: Children with chronic renal failure in the west germany 2. primary renal diseases age and intervals from early renal failure to renal death. In a retrospective survey, 623 children with chronic renal failure (CRF) comprising a 7-yr period were registered in west Germany. The primary renal disease could be classified in 91% of the patients. Pyelonephritis was the most frequent diagnosis...

Wingen, A.M.; Fabian-Bach, C.; Mehls, O., 1991: Low-protein diet in children with chronic renal failure--1-year results. European Study Group for Nutritional Treatment of Chronic Renal Failure in Childhood. In 1988 the European Study for Nutritional Treatment of Children with Chronic Renal Failure started its multicentre randomized trial to investigate the influence of protein intake on the progression of renal failure. A total of 284 children had be...