EurekaMag.com logo
+ Site Statistics
References:
52,725,316
Abstracts:
28,411,598
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

TRH stimulation test in normal and in thyroid disorders


Journal of the Medical Association of Thailand 67(10): 553-561
TRH stimulation test in normal and in thyroid disorders
The normal and abnormal responses of TSH to synthetic TRH in 71 normal Thais and in 54 patients with thyroid disorders were defined. The concentrations of serum TSH were determined by double antibody RIA [radioimmunoassay] before and after giving 200 .mu.g of TRH at 20 and 60 min. The results revealed that normal individuals responded to TRH with reproducible increments in serum TSH. The means .+-. SE of TSH response to TRH in 71 euthyroid subjects were 1.5 .+-. 0.2 mIU/l at basal level, 13.0 .+-. 0.9 mIU/l at 20 min and 9.6 .+-. 0.7 mIU/ml at 60 min. The mean maximum increments in serum TSH at 20 min were found to be 12.0 .+-. 0.9 mIU/l with a range of 7-22 mIU/l. Sex and age differences were evaluated and the results indicated that the basal TSH levels in 48 normal females and in 23 males were not different. Hyperthyroid patients (31) showed a total lack of response to TRH and very low mean values of serum TSH at 0, 20 and 60 min were 0.5 .+-. 0.1, 0.5 .+-. 0.1 and 0.4 .+-. 0.04 mIU/l, respectively. In contrast to hyperthyroidism, all patients with primary hypothyroidism had markedly elevated baseline TSH levels. These findings suggest that the TSH response to TRH should be a sensitive and effective test in the diagnosis of thyroidal dysfunction and this test may have promise in replacing or complementing the tedious thyroid-suppression test. TRH stimulation can be used as a test of pituitary-hypothalamic function with regard to TSH.


Accession: 006839815

PMID: 6440942



Related references

Observations on the stimulation of thyroid function in mice by the injection of serum from normal subjects and from patients with thyroid disorders. Clin Sci [london] 23(3): 463-475, 1962

Behavior of the ETR test after suppression and stimulation in functional disorders of the thyroid gland. Radiobiologia, Radiotherapia 16(6): 767-771, 1975

Importance of the thyrotropin-releasing hormone (TRH) stimulation test in latent thyroid functional disorders. Annales D'endocrinologie 35(2): 195-198, 1974

Clinical experience with the thyrotrophin releasing hormone (TRH) stimulation test in patients with thyroid, pituitary and hypothalamic disorders. Acta Endocrinologica 72(4): 697-713, 1973

Clinical experience with the thyrotropin releasing hormone stimulation test in patients with thyroid pituitary and hypothalamic disorders. Acta Endocrinologica 72(4): 697-713, 1973

Value of the thiocyanate test in the plateau curves of thyroid disorders (thyrosis and hyperthyroidism) during the thyroid function test by radioactive iodine. Pathologie et Biologie 7: 1343-1347, 1959

The TRH test in normal subjects and in thyroid pathology: behavior of plasma TSH after stimulation with hypothalamic TRH (thyrotropin releasing hormone). L'ateneo Parmense. Acta Bio-Medica 44(5): 307-321, 1973

Results of the calcitonin stimulation test in normal volunteers compared with genetically unaffected members of MEN 2A and familial medullary thyroid carcinoma families. Annales D'endocrinologie 58(4): 302-308, 1997

Action of vitamins A, C and D on the normal thyroid and on the thyroid stimulated by the active principle of the anterior pituitary: inhibiting action of vitamin A and of ascorbic acid on experimental thyroid stimulation. C.R. Soc. Biol, 120: 560-562, 1935

Thyroid gland function test and analysis of thyroid antibody using the thyroid test and microsome test in thyroid diseases. Nihon Naibunpi Gakkai Zasshi 50(3): 704-710, 1974