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Trh test and male uni polar depression

, : Trh test and male uni polar depression. Biological Psychiatry 16(9): 819-824

Change in maximal TSH response to a TRH infusion were measured in 18 unipolar depressed males and 2 control groups matched for age, sex and base-line thyroid status. The mean maximal change in TSH response was significantly lower for the unipolar than the control groups. Clinical and research implications of these findings are discussed. By using a .DELTA.TSH cutoff of 7.0 rather than 5 .mu.IU/ml, 14 rather than 7 depressed patients were correctly identified as having a blunted .DELTA.TSH; 29 rather than 32 or 36 control patients were correctly identified as having a normal .DELTA.TSH score.

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Related references

Extein I.; Pottash A.L.C.; Gold M.S.; Goodwin F.K., 1981: Relationship of trh test and dexamethasone suppression test abnormalities in uni polar depression. Psychopharmacology Bulletin 17(3): 177-178

Extein I.; Pottash A.L.C.; Gold M.S., 1981: The trh test in the diagnosis of uni polar depression. The establishment of criteria for a blunted TSH response to TRH may prove useful in distinguishing patients with major unipolar depression from patients with non-major depressions and controls. To this end, we administered the TRH test to a group...

Sternbach H.A.; Kirstein L.; Pottash A.L.C.; Gold M.S.; Extein I.; Sweeney D.R., 1983: The trh test and urinary 3 methoxy 4 hydroxyphenyl glycol in uni polar depression. Men (25) and women (26) with major unipolar depression were evaluated by the TRH test and urinary MHPG [3-methoxy-4-hydroxyphenyl glycol] excretion. A significant positive correlation between TSH response to TRH and urinary MHPG was found in the m...

Coryell W.; Zimmerman M., 1984: Outcome following electro convulsive therapy for primary uni polar depression a test of newly proposed response predictors. This study considered dexamethasone suppression test (DST) results, Winokur's familial subtyping and the presence or absence of melancholia according to DSM-III (Diagnostic and Statistical Manual of Mental Disorders III) criteria as potential...

Golstein J.; Van Cauter E.; Linkowski P.; Vanhaelst L.; Mendlewicz J., 1980: Thyrotropin nycthemeral pattern in primary depression differences between uni polar and bi polar women. The nyctohemeral patterns of serum thyrotropin (TSH) levels were studied in 13 female patients suffering from primary affective illness (5 bipolars and 8 unipolars); they were compared to the nyctohemeral profiles obtained in 6 normal female subje...

Dunner D.L., 1980: Uni polar and bi polar depression recent findings from clinical and biologic studies. Mendels, J And J D Amsterdam (Ed ) The Psychobiology Of Affective Disorders; Pfizer Symposium on Depression, Boca Raton, Fla , Usa, Feb 28-29, Viii+220p S Karger: Basel, Switzerland; New York, N Y , Usa Illus Paper P11-24

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Agren, H.; Terenius, L., 1983: Depression and cerebro spinal fluid endorphin fraction 1. seasonal variation and higher levels in uni polar than bi polar patients. Radioreceptor assay of endorphin Fraction I in the CSF of 92 inpatients suffering from major depression revealed the following: clearly elevated levels as compared to normal control subjects, higher levels in unipolar than in bipolar patients, and...

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