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Tri chloro ethylene and halothane inhibit uptake of 5 hydroxy tryptamine in the isolated perfused rat lung

, : Tri chloro ethylene and halothane inhibit uptake of 5 hydroxy tryptamine in the isolated perfused rat lung. Biochemical Pharmacology 31(3): 353-358

Lung uptake of 5-hydroxytryptamine (5-HT) was determined in isolated perfused and ventilated rat lung, and was found to decrease with time according to a 2-compartmental model. When the lungs were exposed to either trichlorethylene (TRI, a hazardous industrial solvent) or halothane (industrial solvents), the uptake of 5-HT was drastically reduced. Both TRI and halothane gave log dose inhibition curves, which were superimposed, i.e., they were equally potent in inhibiting lung uptake of 5-HT. At a TRI concentration of 18,000 ppm, the extraction of 5-HT was inhibited by 80 .+-. 2% (.hivin.x .+-. SEM [standard error of the mean]), at 8500 ppm the inhibition was 65 .+-. 6% and 25 .+-. 1% at 3000 ppm. When the lungs were exposed to halothane, the inhibition was 85 .+-. 6% at 40,000 ppm, 48 .+-. 1% at 6000 ppm, and 15 .+-. 0.3% at 2000 ppm. When exposure to the solvent was discontinued, extraction of 5-HT was rapidly normalized. There was no detectable displacement of [3H]-5-HT from lungs saturated with the amine when they subsequently were exposed to solvent-containing atmosphere. This inhibition of lung uptake of 5-HT from the circulation is therefore postulated as to be an effect dependent on concentration solvent in the tissue, and is probably due to a reversible membrane stabilization of the endothelium.

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