EurekaMag.com logo
+ Site Statistics
References:
52,725,316
Abstracts:
28,411,598
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Tri chloro ethylene carbon tetra chloride and gasoline intoxication in connection with arterio sclerosis and coronary sclerosis


Archives of Toxicology 35(4): 295-318
Tri chloro ethylene carbon tetra chloride and gasoline intoxication in connection with arterio sclerosis and coronary sclerosis
Autopsies of 4 adolescents who had sniffed and occasionally drunk trichloroethylene, carbon tetrachloride and gasoline revealed severe arteriosclerotic damage of the coronary vessels. Experimental intoxication of 12 rabbits with these solvents over a period of 10 wk, each time until a prenarcotic stage, provoked pathological changes in accordance with well known findings but no arteriosclerosis. Ergometrical examination with simultaneous recording of the ECG of 6 adolescents with solvent-sniffing history and of 1 man, working for years under trichlorethylene exposure conditions and showing symptoms of chronic intoxication, revealed no signs of coronary-artery insufficiency. These findings are not inconsistent with the assumption of a causal relationship between the intoxication with trichloroethylene, carbon tetrachloride and gasoline and the development of arteriosclerosis, since the coronary sclerosis may be of the elastic type with a very high degree of adaptability and the probands proved unable to reach the limit of maximum stress. The occurrence of epileptic seizures following chronic trichlorethylene sniffing in 1 case and the manifestation of pulmonary obstruction following i.v. application of methylphenidate (Ritalin) in 2 cases are also reported.


Accession: 006839898



Related references

Trichlorethylene-, carbon tetrachloride- and gasoline-intoxication in connection with arterio- and coronary sclerosis. Archives of Toxicology 35(4): 295-318, 1976

Hepato toxicity of tri chloro ethylene carbon tetra chloride mixtures in rats a possible consequence of the potentiation by tri chloro ethylene of carbon tetra chloride induced lipid per oxidation and liver lesions. Gastroenterology 83(4): 761-772, 1982

Hepato toxic potency of various chlorinated hydro carbon vapors relative to their narcotic and lethal potencies in mice carbon tetra chloride chloroform cent depress enz glutamic pyruvic transaminase di chloro methane 1 1 1 tri chloro ethane 1 1 2 tri chloro ethane tetra chloro ethylene tri chloro ethylene. Toxicology & Applied Pharmacology 13(3): 287-298, 1968

Relations between carbon tetra chloride induced chronic hepatic disease vitamin d intolerance and occurrence of peripheral arterio sclerosis in rabbits. Circulation Supplement 44(4): II-16, 1971

Inhibition of liver microsome calcium pump by in vivo administration of carbon tetra chloride tri chloro methane and 1 1 di chloro ethylene vinylidene chloride. Biochemical Pharmacology 29(18): 2505-2512, 1980

Studies on the lipid metabolism in arterio sclerosis part 1 total cholesterol value and fatty acid composition of plasma in coronary sclerosis and cerebro vascular sclerosis. Tohoku Igaku Zasshi 78(1): 14-19, 1968

Effect of temperature and commodity on distribution of carbon tetra chloride carbon di sulfide 8020 and ethylene di chloride carbon tetra chloride 7525 applied by gravity penetration and closed recirculation. Journal Of Economic Entomology: 227-230, 1971

Potentiation by tri chloro ethylene of carbon tetra chloride induced lipid per oxidation and liver lesions in rats. Gastroenterologie Clinique et Biologique 6(10): 807, 1982

Carbon tetra chloride levels and serum activities of liver enzymes following acute carbon tetra chloride intoxication. Toxicology Letters (Shannon) 17(1-2): 175-180, 1983

Whole body auto radiography and allied tracer techniques in distribution and elimination studies of some organic solvents benzene toluene xylene styrene methylene chloride chloroform carbon tetra chloride and tri chloro ethylene. Acta Pharmaceutica Suecica 16(5): 349-350, 1979