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Tri chloro ethylene carbon tetra chloride and gasoline intoxication in connection with arterio sclerosis and coronary sclerosis


, : Tri chloro ethylene carbon tetra chloride and gasoline intoxication in connection with arterio sclerosis and coronary sclerosis. Archives of Toxicology 35(4): 295-318

Autopsies of 4 adolescents who had sniffed and occasionally drunk trichloroethylene, carbon tetrachloride and gasoline revealed severe arteriosclerotic damage of the coronary vessels. Experimental intoxication of 12 rabbits with these solvents over a period of 10 wk, each time until a prenarcotic stage, provoked pathological changes in accordance with well known findings but no arteriosclerosis. Ergometrical examination with simultaneous recording of the ECG of 6 adolescents with solvent-sniffing history and of 1 man, working for years under trichlorethylene exposure conditions and showing symptoms of chronic intoxication, revealed no signs of coronary-artery insufficiency. These findings are not inconsistent with the assumption of a causal relationship between the intoxication with trichloroethylene, carbon tetrachloride and gasoline and the development of arteriosclerosis, since the coronary sclerosis may be of the elastic type with a very high degree of adaptability and the probands proved unable to reach the limit of maximum stress. The occurrence of epileptic seizures following chronic trichlorethylene sniffing in 1 case and the manifestation of pulmonary obstruction following i.v. application of methylphenidate (Ritalin) in 2 cases are also reported.

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