+ Translate

Tri chloro ethylene hepato toxicity in rats treated with barbiturates or ethanol

, : Tri chloro ethylene hepato toxicity in rats treated with barbiturates or ethanol. Research Communications in Substances of Abuse 5(1): 67-76

The potential liver toxicity of trichloroethylene [TRI], a widely used environmental pollutant, was investigated with an experimental model reflecting possible human exposure at work. TRI was given to rats by inhalation alone or in association with EtOH [ethanol] or PB [phenobarbitone] in the drinking water for 2 mo. BW [body weight], serum ALT [alanine aminotransferase], SDH [sorbitol dehydrogenase] and TBA [serum total bile acids] were not significantly affected. An increase in RLW [relative liver weight] after PB was seen as evidence of augmented efficiency of the mixed-function oxidase system, since hexobarbital narcosis was shortened by 50%. Depressed liver TG [triglyceride] was noted after TRI administered alone. Changes in BSP [bromosulphophthalein] and SOR [sorbitol] clearance suggested that TRI was responsible for certain functional changes in the liver, even though the usual indicators of toxicity were virtually unaffected.

(PDF 0-2 workdays service)

Order PDF Full Text


Click here to order any other PDF Full Text

Accession: 006839903

PDF Full Text: Submit

Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:

Other references

Johnson, Wm, 1975: Classification and mapping of prime and unique farmlands. Perspectives on Prime Lands Background Papers for Seminar on Retention of Prime Lands: 89-198

Gutu, Modest; Heard, Richard, W., 2002: A new genus and species of a new family of apseudomorph tanaidaceans (Crustacea: Peracarida) from Australian waters. Numbakulla pygmaeus n. g., n. sp., the type for the new family Numbakullidae of apseudomorph tanaidaceans, is described and illustrated. Specimens of Numbakulla pygmaeus were collected in depths of 81-84 m on the Continental Shelf off northwestern...

Bratke, K; Krieghoff, L; Kuepper, M; Luttmann, W; Virchow, Jc, 2007: CD8 T cell activation and differentiation in allergic asthma and the impact of cytomegalovirus serological status. Allergic asthma is a chronic inflammatory T helper 2 (Th2)-associated disease. There is evidence that the atopic milieu affects the development of CD8 T cells in patients. We therefore analysed activation and differentiation states of CD8 T cells...

Lotery, Andrew J.; Munier, Francis L.; Fishman, Gerald A.; Weleber, Richard G.; Jacobson, Samuel G.; Affatigato, Louisa M.; Nichols, Brian E.; Schorderet, Daniel F.; Sheffield, Val C.; Stone, Edwin M., 2000: Allelic variation in the VMD2 gene in Best disease and age-related macular degeneration. PURPOSE: To assess the allelic variation of the VMD2 gene in patients with Best disease and age-related macular degeneration (AMD). METHODS: Three hundred twenty-one AMD patients, 192 ethnically similar control subjects, 39 unrelated probands with...

Nisonoff A., 1984: Introduction to molecular immunology 2nd edition. This text is meant to be used for introductory molecular immunology courses. This 2nd edition contains a new chapter on molecules encoded by the major histocompatibility complex. The chapters on the organization of genes controlling immunoglobulin...

Gallagher, R. S.; Fuerst, E. P., 2006: The ecophysiological basis of weed seed longevity in the soil. This chapter presents a conceptual model that outlines the plant, soil and climatic factors contributing to weed seed longevity in the soil. The interacting processes regulating weed seed longevity are also discussed, excluding predation.

Aguilar Marcelo; Caus Esmeralda, 1998: Orbitocyclina minima (Douville); an index fossil for the Campanian in Mexico. Memoria del

Lisovsky N. N.; Zolotov A. N.; Avrov V. P.; Krylov N. A.; Dvurechensky V., 1992: Pre-Caspian Depression; the area of huge hydrocarbon accumulations. Proceedings - World Petroleum Congress = Actes et Documents - Congres Mondial du Petrole 13, Vol

Karagiogos A.; Garcia J.F.; Brooks G.A., 1979: Growth hormone response to continuous and intermittent exercise. The hypothesis that human growth hormone (hGH) secretion during exercise is related to anaerobic metabolism, and therefore blood lactic acid (LA), was tested. Ten males (20-30 yr) were observed during 40 min of continuous cycle ergometer exercise...

Furlan, A. C.; Faria, H. G. de; Scapinello, C.; Moreira, I.; Murakami, A. E.; Santolin, M. L. da R., 2001: The digestibility of sunflower meal and effect on the performance of growing rabbits. Two trials were carried out to determine the nutritive value and the performance of rabbits fed on diets containing sunflower meal. For the digestibility trial, 50-day-old New Zealand White rabbits (n=20) were used in a completely randomized desig...