EurekaMag.com logo
+ Site Statistics
References:
53,517,315
Abstracts:
29,339,501
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Tri chloro ethylene hepato toxicity in rats treated with barbiturates or ethanol



Tri chloro ethylene hepato toxicity in rats treated with barbiturates or ethanol



Research Communications in Substances of Abuse 5(1): 67-76



The potential liver toxicity of trichloroethylene [TRI], a widely used environmental pollutant, was investigated with an experimental model reflecting possible human exposure at work. TRI was given to rats by inhalation alone or in association with EtOH [ethanol] or PB [phenobarbitone] in the drinking water for 2 mo. BW [body weight], serum ALT [alanine aminotransferase], SDH [sorbitol dehydrogenase] and TBA [serum total bile acids] were not significantly affected. An increase in RLW [relative liver weight] after PB was seen as evidence of augmented efficiency of the mixed-function oxidase system, since hexobarbital narcosis was shortened by 50%. Depressed liver TG [triglyceride] was noted after TRI administered alone. Changes in BSP [bromosulphophthalein] and SOR [sorbitol] clearance suggested that TRI was responsible for certain functional changes in the liver, even though the usual indicators of toxicity were virtually unaffected.

(PDF 0-2 workdays service: $29.90)

Accession: 006839903

Download citation: RISBibTeXText



Related references

Hepato toxicity of 1 1 di chloro ethylene influence of altered thyroid function in rats. Toxicology & Applied Pharmacology 37(1): 174-175, 1976

Hepato toxicity of tri chloro ethylene carbon tetra chloride mixtures in rats a possible consequence of the potentiation by tri chloro ethylene of carbon tetra chloride induced lipid per oxidation and liver lesions. Gastroenterology 83(4): 761-772, 1982

Enhancement of the metabolism and hepato toxicity of tri chloro ethylene and per chloro ethylene. Biochemical Pharmacology 26(5): 369-376, 1977

Effect of 18 hour fast and glutathione depletion of 1 1 di chloro ethylene induced hepato toxicity and lethality in rats. Experimental & Molecular Pathology 20(2): 187-198, 1974

Embryo toxicity and feto toxicity of inhaled tri chloro ethylene per chloro ethylene methyl chloroform and methylene chloride in mice and rats. Toxicology & Applied Pharmacology 33(1): 136, 1975

Mechanism for tri chloro ethylene hepato toxicity. Digestion 16(4): 331-332, 1977

Carcinogenic activity of ethylene oxide and its reaction products 2 chloro ethanol 2 bromo ethanol ethylene glycol and di ethylene glycol 2. testing of 2 chloro ethanol and 2 bromo ethanol for carcinogenicity. Zentralblatt fuer Bakteriologie Mikrobiologie und Hygiene Abt 1 Originale B Hygiene Umwelthygiene Krankenhaushygiene Arbeitshygiene Praeventive Medizin 177(3-4): 269-281, 1983

Hepato toxicity of 1 1 di chloro ethylene a proposed mechanism. Toxicology & Applied Pharmacology 41(1): 187-188, 1977

Hepato toxicity of vinyl chloride and 1 1 di chloro ethylene. American Journal of Pathology 81(1): 219-236, 1975

Modification of 1 1 di chloro ethylene hepato toxicity by hypo thyroidism. Toxicology and Applied Pharmacology 42(2): 367-376, 1977

Hepato toxic potency of various chlorinated hydro carbon vapors relative to their narcotic and lethal potencies in mice carbon tetra chloride chloroform cent depress enz glutamic pyruvic transaminase di chloro methane 1 1 1 tri chloro ethane 1 1 2 tri chloro ethane tetra chloro ethylene tri chloro ethylene. Toxicology & Applied Pharmacology 13(3): 287-298, 1968

1 1 di chloro ethylene hepato toxicity time course of glutathione changes and biochemical aberrations. American Journal of Pathology 101(2): 331-344, 1980

1 di chloro ethylene hepato toxicity time course of glutathione changes and biochemical aberrations. American Journal Of Pathology: 331-344, 1980

Histochemical evidence that mitochondria are foci of 1 1 di chloro ethylene hepato toxicity. Federation Proceedings 38(3 PART 1): 1340, 1979

Hepato renal toxicity from sniffing spot remover tri chloro ethylene. American Journal of Digestive Diseases 15(9): 851-856, 1970