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Tri chloro ethylene hepato toxicity in rats treated with barbiturates or ethanol

, : Tri chloro ethylene hepato toxicity in rats treated with barbiturates or ethanol. Research Communications in Substances of Abuse 5(1): 67-76

The potential liver toxicity of trichloroethylene [TRI], a widely used environmental pollutant, was investigated with an experimental model reflecting possible human exposure at work. TRI was given to rats by inhalation alone or in association with EtOH [ethanol] or PB [phenobarbitone] in the drinking water for 2 mo. BW [body weight], serum ALT [alanine aminotransferase], SDH [sorbitol dehydrogenase] and TBA [serum total bile acids] were not significantly affected. An increase in RLW [relative liver weight] after PB was seen as evidence of augmented efficiency of the mixed-function oxidase system, since hexobarbital narcosis was shortened by 50%. Depressed liver TG [triglyceride] was noted after TRI administered alone. Changes in BSP [bromosulphophthalein] and SOR [sorbitol] clearance suggested that TRI was responsible for certain functional changes in the liver, even though the usual indicators of toxicity were virtually unaffected.

Accession: 006839903

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Jaeger R.J.; Szabo S.; Coffman L.; Moslen M.T.; Reynolds E.S.; Murphy S.D., 1976: Hepato toxicity of 1 1 di chloro ethylene influence of altered thyroid function in rats. Toxicology & Applied Pharmacology 37(1): 174-175

Pessayre D.; Cobert B.; Descatoire V.; Degott C.; Babany G.; Funck Brentano C.; Delaforge M.; Larrey D., 1982: Hepato toxicity of tri chloro ethylene carbon tetra chloride mixtures in rats a possible consequence of the potentiation by tri chloro ethylene of carbon tetra chloride induced lipid per oxidation and liver lesions. Liver histology was normal 24 h after the administration of trichloroethylene (1 ml/kg) in rats. It was normal, or showed necrosis of a few hepatocytes, after the administration of CCl4 (64 .mu.l/kg). In rats receiving both solvents, there was ext...

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