Tri chloro ethylene hepato toxicity in rats treated with barbiturates or ethanol

Danni O.; Molino G.; Cavanna A.; Burdino E.; Biondi A.M.; Torchio M.; Urigu S.; Ugazio G., 1984: Tri chloro ethylene hepato toxicity in rats treated with barbiturates or ethanol. Research Communications in Substances of Abuse 5(1): 67-76

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Jaeger R.J.; Szabo S.; Coffman L.; Moslen M.T.; Reynolds E.S.; Murphy S.D., 1976: Hepato toxicity of 1 1 di chloro ethylene influence of altered thyroid function in rats. Toxicology & Applied Pharmacology 37(1): 174-175

Pessayre D.; Cobert B.; Descatoire V.; Degott C.; Babany G.; Funck Brentano C.; Delaforge M.; Larrey D., 1982: Hepato toxicity of tri chloro ethylene carbon tetra chloride mixtures in rats a possible consequence of the potentiation by tri chloro ethylene of carbon tetra chloride induced lipid per oxidation and liver lesions. Liver histology was normal 24 h after the administration of trichloroethylene (1 ml/kg) in rats. It was normal, or showed necrosis of a few hepatocytes, after the administration of CCl4 (64 .mu.l/kg). In rats receiving both solvents, there was ext...

Moslen, M.T.; Reynolds, E.S.; Szabo, S., 1977: Enhancement of the metabolism and hepato toxicity of tri chloro ethylene and per chloro ethylene. Trichloroethylene anesthesia (1% for 2 h) caused acute hepatic injury in rats pretreated with 5 different inducers of the hepatic mixed function oxidase system, phenobarbital, Aroclor 1254, hexachlorobenzene, 3-methylcholanthrene and pregnenolone-...

Jaeger R.J.; Conolly R.B.; Murphy S.D., 1974: Effect of 18 hour fast and glutathione depletion of 1 1 di chloro ethylene induced hepato toxicity and lethality in rats. Experimental & Molecular Pathology 20(2): 187-198

Leong B.K.J.; Schwetz B.A.; Gehring P.J., 1975: Embryo toxicity and feto toxicity of inhaled tri chloro ethylene per chloro ethylene methyl chloroform and methylene chloride in mice and rats. Toxicology & Applied Pharmacology 33(1): 136

Allemand H.; Pessayre D.; Descatoire V.; Degott C.; Feldmann G.; Benhamou J P., 1977: Mechanism for tri chloro ethylene hepato toxicity. Digestion 16(4): 331-332

Dunkelberg, H., 1983: Carcinogenic activity of ethylene oxide and its reaction products 2 chloro ethanol 2 bromo ethanol ethylene glycol and di ethylene glycol 2. testing of 2 chloro ethanol and 2 bromo ethanol for carcinogenicity. The compounds 2-chloroethanol and 2-bromoethanol were administered 1/wk s.c. to groups of 100 female NMRI mice, in the cae of 2-chloroethanol in 3 dosages (3.0, 1.0 and 0.3 mg, single dosage per mouse) and 2-bromoethanol in 2 dosages (1.0 and 0.3...

Jaeger R.J.; Coffman L., 1977: Hepato toxicity of 1 1 di chloro ethylene a proposed mechanism. Toxicology & Applied Pharmacology 41(1): 187-188

Reynolds E.S.; Treinen Moslen M.; Szabo S.; Jaeger R.J.; Murphy S.D., 1975: Hepato toxicity of vinyl chloride and 1 1 di chloro ethylene. American Journal of Pathology 81(1): 219-236

Szabo, S.; Jaeger, R.J.; Moslen, M.T.; Reynolds, E.S., 1977: Modification of 1 1 di chloro ethylene hepato toxicity by hypo thyroidism. Exposure of fasted male rats for 4 h to 2000 ppm of 1,1-dichloroethylene (1,1-DCE), which decreased hepatic contents of reduced glutathione (GSH), resulted in severe liver injury by 2 h, as manifested by morphologic and histochemical (i.e., Ca and...