EurekaMag.com logo
+ Site Statistics
References:
48,253,228
Abstracts:
22,798,842
+ Resolve Accession
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
Submit PDF Full TextSubmit PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Tri cyclic anti depressants in serum by a clin elut column extraction and high pressure liquid chromatographic analysis


, : Tri cyclic anti depressants in serum by a clin elut column extraction and high pressure liquid chromatographic analysis. Therapeutic Drug Monitoring 1(3): 335-358

A method for routine therapeutic monitoring of serum tricyclic antidepressants (TCA) which offered good reproducibility, detection limits, linearity and specificity and which was simple, rapid and inexpensive to perform was developed. The method described uses Clin-Elut columns to facilitate the extraction. The analysis is by high pressure liquid chromatography (HPLC) with a CN bonded phase column, a mobile phase of acetonitrile/pH 7.0 phosphate/methanol and detection at 210 nm. This chromatographic system gives short equilibration times, stable calibration curves, high sensitivity and resolution, short retention times and long column life. The method is useful for determination of amitriptyline, doxepine, imipramine, nortriptyline, nordoxepin, desipramine and protriptyline. Trimipramine is used as an internal standard for the tertiary amines and protriptyline for the secondary amines. Recovery is linear from 25-1000 ng/ml. Rubber stoppers of a new formulation in Vacutainer blood collection tubes do not affect serum TCA levels. Sera from 53 psychiatric patients suffering from endogenous depression were analyzed using the procedure presented. The mean serum level of 4 patients on amitriptyline therapy having complete remission was 201 ng/ml (range, 123-259). The mean serum level of 4 patients on imipramine therapy rated as having complete remission was 200 ng/ml (range, 145-258). These values compare with recently published therapeutic ranges.

(PDF 0-2 workdays service)

Order PDF Full Text

Close
Close

Click here to order any other PDF Full Text


Accession: 006839950

PDF Full Text: Submit


Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:
Close
Close

Other references

Faraglia, Giuseppina; Fregona, Dolores; Sitran, Sergio; Giovagnini, Lorena; Marzano, Cristina; Baccichetti, Francarosa; Casellato, Umberto; Graziani, Rodolfo, 2001: Platinum(II) and palladium(II) complexes with dithiocarbamates and amines: Synthesis, characterization and cell assay. The (M(ESDT)Cl)n (M=Pd or Pt; ESDT=EtO2CCH2(CH3)NCS2-, methylamino-acetic acid ethyl ester-dithiocarboxylate) species have been reacted with various amines (py, pyridine; PrNH2, n-propylamine; c-BuNH2, cyclobutylamine; en, ethylenediamine) in dich...

Hillam C., 1987: Professional education for dentistry before 1859. British Dental Journal: 204-207

Phillips, Donald L.; Eldridge, Peter M., 2006: Estimating the timing of diet shifts using stable isotopes. Stable isotope analysis has become an important tool in studies of trophic food webs and animal feeding patterns. When animals undergo rapid dietary shifts due to migration, metamorphosis, or other reasons, the isotopic composition of their tissue...

Marik, Paul, E.; Stauffer, Robert; Anto, Soetji; Mcnichol, Mary; Feldman, Arthur; Riggio, Jeff, 2006: An intranet-based system for inpatient billing in an academic medical center. Academic physicians face great economic challenges. There is therefore a growing need to increase the efficiency of academic practice. One potential target for improving the "business" of medicine is inpatient billing. Currently many aca...

Anonymous, 1965: Katumani programme for early maturity maize. Seed bulking and distribution. Katumani Synthetic IV produces a 23% increase in yield over Katumani Synthetic II in the Machakos and Kitu districts of the Eastern Province. Katumani Synthetic II x Synthetic III has averaged a 27% increased yield over the parental synthetics. As...

Miller, P. M.; Linn, M. B., 1954: The efficacy of fungicides in the control of certain genera of plant pathogenic fungi: a literature review. An evaluation, based on data obtained from the literature (68 titles) over the period 1942-52, is made of the comparative effectiveness of 17 types (33 formulations) of fungicides against 23 plant-pathogenic species of Alternaria, Cercospora, Coll...

Weiner, Louis M., 1999: An overview of monoclonal antibody therapy of cancer. Seminars in Oncology 26(4 SUPPL 12): 41-50, Aug

Esker, P. D.; Obrycki, J.; Nutter, F. W, Jr, 2002: Temporal distribution of Chaetocnema pulicaria (Coleoptera: Chrysomelidae) populations in Iowa. In 1999 and 2000, yellow sticky cards and sweep net samples were used to document the occurrence of an overwintering adult generation of Chaetocnema pulicaria Melsheimer, corn flea beetle, followed by two distinct populations peaks during the grow...

Stiles, J. R.; Kovyazina, I. V.; Van Der Kloot, W.; Salpeter, M. M., 1998: Optimized recordings and physiological implications of rapid miniature endplate current rise times. Society for Neuroscience Abstracts 24(1-2): 826

Shafer,J.M.; Brantley,D.T.; Waddell,M.G., 2010: Variable-density flow and transport simulation of wellbore brine displacement. Borehole dilution tests have been used for characterization of aquifer hydrogeologic properties for several decades. Based on the principles of borehole dilution tests, we conducted what more appropriately may be considered a wellbore fluid displa...