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Tri dimensional study of the deep cortex of the rat lymph node 8. the deep cortex units of the athymic nude rat


, : Tri dimensional study of the deep cortex of the rat lymph node 8. the deep cortex units of the athymic nude rat. Anatomical Record 209(1): 95-104

The deep cortex of the lymph node of various species actually consists of hemispherical structures, termed deep cortex units. Each unit is centered under an opening of an afferent lymphatic and comprises a center and a periphery. In a recent work on the nude mouse, it was found that the congenital athymic state inhibits the development of the lymphocyte population in the center of the units as well as in a related area of peripheral cortex, and that it also modifies other nodal components. Here effects were studied of the athymic state on the rat nodes. Nodes from various anatomical locations in 8-wk-old nude rats were submitted to a tridimensional analysis. Overall effects of the congenital athymic state were comparable in rats and mice. Marked differences were noticed in the modifications of the node histology, in both species of nude animals. Their significance is discussed, together with new findings.

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