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Tri ethyl lead restrained myelin deposition and protein synthesis in the developing rat fore brain


, : Tri ethyl lead restrained myelin deposition and protein synthesis in the developing rat fore brain. Experimental Neurology 52(1): 58-65

Rats (20 day old) were acutely intoxicated with triethyllead (PbEt3). The forebrains of the poisoned and control animals were analyzed on postpartum days 27 or 34, or both. Two myelin subfractions, namely membrane- and myelin-fraction, were isolated. In the forebrains of PbEt3-treated rats, the deposition of the membrane-fraction was hampered to a greater extent than the deposition of the myelin-fraction. The intoxication caused a significant reduction in the concentration of sulfatides in the myelin-fraction. In spite of sulfatides, the intoxication did not influence the protein or lipid content of either subfraction. A close correlation between the degree of inhibition of myelin deposition and of synthesis of myelin proteins was demonstrated in the forebrains of PbEt3-intoxicated rats. The synthesis of total forebrain protein was less depressed than the synthesis of myelin or its proteins, suggesting greater vulnerability of the myelin-forming cells than other cells in the brain tissue toward PbEt3-induced intoxication.

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Accession: 006839992

PMID: 954911

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Konat G.; Offner H.; Clausen J., 1979: The effect of tri ethyl lead on total and myelin protein synthesis in rat fore brain slices. Rats (20 day old) were acutely intoxicated with triethyllead [PbEt3] and their forebrains were studied during the following 14 days. All the Pb in the tissue was found in the form of PbEt3, proving that the toxin per se was responsible for the pat...

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