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Tri ethylene melamine an initiator of 2 stage carcinogenesis in mouse skin which lacks the potential of a complete carcinogen



Tri ethylene melamine an initiator of 2 stage carcinogenesis in mouse skin which lacks the potential of a complete carcinogen



Cancer Letters 21(1): 37-42



The dorsal skin of female CD-1 mice was treated with triethylenemelamine (TEM) to determine whether this agent acted either as a complete carcinogen or as an initiator of carcinogenesis. A dose of 0.01-1.0 .mu.mol of TEM applied 1/wk for 32 wk to the skin of the backs of mice did not produce any detectable tumors. A dose of 2.5 .mu.mol applied 1/wk over the same period produced only a single papilloma in a group of 20 mice. When mice were treated with a single dose of 1 .mu.mol of TEM followed by promotion with 12-O-tetradecanoylphorbol-13-acetate (TPA) twice a week, 88% of the mice produced papillomas after 28 wk. Using the same protocol, a single application of hexamethylmelamine (HMM), pentamethylmelamine (PMM), or melamine followed by promotion with TPA had no significant tumor initiating activity. TEM may act primarily as an initiator of 2-stage carcinogenesis.

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