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Tri iodo thyromine kinetics in eu thyroid graves disease patients who exhibit hyper responsiveness to trh after radio iodine treatment

Tri iodo thyromine kinetics in eu thyroid graves disease patients who exhibit hyper responsiveness to trh after radio iodine treatment

Clinical Endocrinology 15(4): 417-421

A major reduction in T3 [triiodothyronine] was demonstrated previously in clinically hypothyroid patients. This study used non-compartmental (NC) and mono-compartmental (MC) analysis to study 10 patients with Graves' disease who, following treatment with radioactive iodine (RAI), are now clinically euthyroid but who showed hyper-responsiveness to TRH although serum T3 and thyroxine concentrations are within the normal range. T3 production rate (PR), metabolic clearance rate (MRC) and fractional-turnover (K) were all significantly reduced in patients compared with 7 controls (P < 0.01). T3, MCR and PR were consistently higher, and T3 K lower, when calculated by MC, than values calculated by NC analysis. The difference in T3 production rates between patients (mean 16.6 nmol/day) and controls (mean 38.9 nmol/day) raises the question of replacement therapy in patients who are apparently euthyroid but TRH hyper-responsive.

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