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Tri olein emboli clearance from the mouse lung effect of heparin and heparitin sulfate


Experimental and Molecular Pathology 25(1): 60-69
Tri olein emboli clearance from the mouse lung effect of heparin and heparitin sulfate
A model system was designed in mice in which the localization, accumulation and clearance of experimentally induced pulmonary fat emboli can be studied. When 125I-labeled triolein emulsions are injected via the caudal vein, the lipid is trapped predominantly in the lung vasculature. Both heparin and heparitin sulfate significantly lowered the level of trapped 125I-labeled triolein in the lungs compared to control mice and caused the release of significant amounts of lipoprotein lipase into the plasma. A possible mechanism is suggested for clearance of triglycerides from the lung vasculature may involve the release of plasma lipoprotein lipase. This is turn hydrolyzes the localized glycerides into more water-soluble components, so they can be removed from the embolization site.


Accession: 006840247

PMID: 133819



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