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Tri olein emboli clearance from the mouse lung effect of heparin and heparitin sulfate



Tri olein emboli clearance from the mouse lung effect of heparin and heparitin sulfate



Experimental and Molecular Pathology 25(1): 60-69



A model system was designed in mice in which the localization, accumulation and clearance of experimentally induced pulmonary fat emboli can be studied. When 125I-labeled triolein emulsions are injected via the caudal vein, the lipid is trapped predominantly in the lung vasculature. Both heparin and heparitin sulfate significantly lowered the level of trapped 125I-labeled triolein in the lungs compared to control mice and caused the release of significant amounts of lipoprotein lipase into the plasma. A possible mechanism is suggested for clearance of triglycerides from the lung vasculature may involve the release of plasma lipoprotein lipase. This is turn hydrolyzes the localized glycerides into more water-soluble components, so they can be removed from the embolization site.

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Accession: 006840247

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PMID: 133819



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