EurekaMag.com logo
+ Site Statistics
References:
52,725,316
Abstracts:
28,411,598
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Trials and tribulations with artificial liver support






Gut 19(6): 578-583

Trials and tribulations with artificial liver support

The experience gained over the past few years in 2 techniques of liver support, charcoal hemoperfusion and polyacrylonitrile (PAN) membrane hemodialysis was reviewed. Problems with charcoal hemoperfusion have centered around platelet aggregation and hypertension, and new C preparations with a variety of different coatings to overcome these problems are described. Hemodialysis using the PAN membrane has caused fewer side-effects in patients and current results show that 33% of patients so treated recover consciousness. The new techniques for liver support currently being developed, including combined dialysis/perfusion systems and those based on plasma separation, are also described.


Accession: 006840601

PMID: 355070

DOI: 10.1136/gut.19.6.578



Related references

The trials and tribulations of the treatment of nonalcoholic fatty-liver disease. Current Opinion in Lipidology 19(6): 592-599, 2008

Liver transplantation in the Asia Pacific region--trials and tribulations. Medical Journal of Malaysia 60 Suppl B: 1-4, 2005

The road to regenerative liver therapies: the triumphs, trials and tribulations. Biotechnology Advances 31(7): 1085-1093, 2014

Tacrolimus for prevention of liver allograft rejection: clinical trials and tribulations. Lancet 346(8986): 1310-1311, 1995

Hepatocyte culture systems for artificial liver support: implications for critical care medicine (bioartificial liver support). Critical Care Medicine 20(8): 1157-1168, 1992

Characterization and propagation of tumor initiating cells derived from colorectal liver metastases: trials, tribulations and a cautionary note. Plos One 10(2): E0117776-E0117776, 2016

Is the biological artificial liver clinically applicable? A historic review of biological artificial liver support systems. Artificial Organs. 18(5): 348-354, 1994

Artificial liver support based on artificial cells with emphasis on encapsulated hepatocytes. Artificial Organs 16(1): 71-74, 1992

Glucose-lowering therapies and cancer risk: the trials and tribulations of trials and observations. Diabetologia 53(9): 1823-1826, 2010

Trials and tribulations of conducting medication trials: pediatric bipolar disorder as prototype. Clinical Investigation 4(11): 993-996, 2015