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Trials and tribulations with artificial liver support

Trials and tribulations with artificial liver support

Gut 19(6): 578-583

The experience gained over the past few years in 2 techniques of liver support, charcoal hemoperfusion and polyacrylonitrile (PAN) membrane hemodialysis was reviewed. Problems with charcoal hemoperfusion have centered around platelet aggregation and hypertension, and new C preparations with a variety of different coatings to overcome these problems are described. Hemodialysis using the PAN membrane has caused fewer side-effects in patients and current results show that 33% of patients so treated recover consciousness. The new techniques for liver support currently being developed, including combined dialysis/perfusion systems and those based on plasma separation, are also described.

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Accession: 006840601

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PMID: 355070

DOI: 10.1136/gut.19.6.578

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