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Triamcinolone acetonide aerosols for asthma part 1 effective replacement of systemic cortico steroid therapy


, : Triamcinolone acetonide aerosols for asthma part 1 effective replacement of systemic cortico steroid therapy. Journal of Allergy and Clinical Immunology 57(1): 1-11

Triamcinolone acetonide, a water-insoluble corticosteroid preparation in a Freon-propelled metered-dose aerosol, was administered via a specially designed nebulizer to 22 adult patients with severe, chronic asthma. All patients had required oral corticosteroid therapy, daily, for several years, to control their incapacitating obstructive airways disease. During 4 wk of treatment with triamcinolone acetonide, taken in 4 daily doses totaling 8 to 28 inhalations (400-1400 .mu.g)/day: asthma remained under satisfactory control; oral corticosteroids were stopped in 19 patients and reduced in 2, and 1 patient withdrew from the study; adrenal cortical function returned to normal or near normal levels; spirometric and plethysmographic measurements improved significantly; daily self-measurements of peak expiratory flow showed a marked improvement in median weekly levels, as well as a reduction in daily variability. No immediate undesirable side effects were noted. More extensive applications of topical corticosteroid therapy are justified as an effective, convenient, and relatively safe method for the preventive management of severe, persistent asthma.

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Related references

Falliers, C.J., 1976: Triamcinolone acetonide aerosols for asthma. I. Effective replacement of systemic corticosteroid therapy. Triamcinolone acetonide, a water-insoluble corticosteroid preparation in a Freon-propelled metered-dose aerosol, was administered via a specially designed nebulizer to 22 adult patients with severe, chronic asthma. All patients had required oral c...

Falliers C.J.; Kennedy P.A.; Petraco A.J.; Vrchota J.A., 1977: Triamcinolone acetonide aerosols for asthma part 3 a double blind confirmation of long term efficacy. Annals of Allergy 39(1): 71

Frey, H.; Norman, N., 1971: Duration of action of depot cortico steroids part 2 triamcinolone acetonide and triamcinolone di acetate. European Journal of Clinical Pharmacology 3(4): 229-231

Scher, R.K., 1964: Triamcinolone Acetonide Intramuscularly: Effective Long-Acting Steroid Therapy In Dermatologic Disorders. Sixty patients representing a variety of clinically distinct dermatoses, both acute and chronic, were treated with intramuscular triamcinolone. The steroid was injected into the deltoid muscle in 40 patients, into the deltoid and then into the glu...

Ordonez E.T., 1971: Pharmacological properties of a new cortico steroid derivative benzoyl beta amino iso butyrate of triamcinolone acetonide. Arzneimittel Forschung: 248-250

Smith, J.G.; Zawisza, R.J.; Blank, H., 1958: Triamcinolone acetonide: a highly effective new topical steroid. A.M.A. Archives of Dermatology 78(5): 643-645

Chervinsky, P., 1977: Treatment of steroid-dependent asthma with triamcinolone acetonide aerosol. Corticosteroids, originally developed as topical agents, have proved effective in aerosol form in the treatment of asthma. Of 33 chronic bronchial asthmatic patients dependent on oral corticosteroids, 16 were randomly selected for treatment with t...

Reed C.E., 1976: A 1 year trial of aerosol triamcinolone acetonide in severe steroid dependent asthma. Journal Of Allergy & Clinical Immunology: 258

Kriz, R.J.; Chmelik, F.; doPico, G.; Reed, C.E., 1977: A one-year trial of triamcinolone acetonide aerosol in severe steroid-dependent asthma. Twenty-three steroid-dependent severely asthmatic patients, ranging in age from 20 to 67 years, tolerated reduction in their oral dosage of steroids during a one-year trial of triamcinolone acetonide aerosol. Sixteen patients maintained their init...

Rowland, V.; Levine, B.E., 1977: Long-term trials of aerosol triamcinolone acetonide in steroid-dependent asthma. Arizona Medicine 31(4): 247-249