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Triascins new inhibitors of acyl coenzyme a synthetase produced by streptomyces sp






Journal of Antibiotics (Tokyo) 39(9): 1211-1218

Triascins new inhibitors of acyl coenzyme a synthetase produced by streptomyces sp

Triacsins A and B, new inhibitors of acyl-CoA synthetase, were isolated from the cultured broth of Streptomyces sp. strain SK-1894. The structurally related compounds WS-1228 A and B, known as hypotensive vasodilators, were also found to inhibit acyl-CoA synthetase. The four compounds have in common N-hydroxytriazene moiety in their structures. The IC30 values for triascin A and WS-1228 A were 5.5 and 3.6 .mu.g/ml, respectively.


Accession: 006840722



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