Tritium labeled delta 9 tetra hydro cannabinol tritium labeled cannabinol and tritium labeled cannabidiol penetration and regional distribution in rat brain

Alozie, S.O.; Martin, B.R.; Harris, L.S.; Dewey, W.L.

Pharmacology Biochemistry and Behavior 12(2): 217-222


ISSN/ISBN: 0091-3057
Accession: 006843141

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3H-.DELTA.9-Tetrahydrocannabinol (3H-.DELTA.9-THC), 3H-cannabidiol (3H-CBD) and 3H-cannabinol (3H-CBN) were administered (1 mg/kg) to male rats which were decapitated 0.5, 1, 15, 30 or 90 min later. The plasma concentration was similar for all cannabinoids throughout the time course. After 5 min, > 80% of the plasma radioactivity in each treatment was due to metabolites. Radioactivity rapidly entered the brain after the administration of 3H-CBD; 3H-CBN, and 3H-.DELTA.9-THC. The concentrations of unchanged 3H-CBD and 3H-CBN in whole brain were higher than that of 3H-.DELTA.9-THC 5 min after administration. Regional distribution of radioactivity in the brain after 5 min was similar for all 3 cannabinoids, the only significant difference being in hypothalamus. Coadministration of 3H-.DELTA.9-THC with a 5-fold excess of CBD or .DELTA.9-THC did not produce any significant alteration in the levels of radioactivity in the brain or plasma 5 min after their injection. The difference in behavioral activity of .DELTA.9-THC, CBD and CBN cannot be explained by penetrability or regional distribution in the brain.