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Trypanosoma cruzi immuno suppressed response to different antigens in the infected mouse

Trypanosoma cruzi immuno suppressed response to different antigens in the infected mouse

Experimental Parasitology 45(2): 190-199

T. cruzi infection in mice results in functional changes in the normal immunological responses to heterologous antigens. An immunosuppression of the 19 and 7S antibody response is observed in infected animals against both a particulate antigen and against soluble antigens. The immune response to the soluble T[thymus]-independent antigens, DNP-Ficoll and LPS [lipopolysaccharide] was similarly impaired when antigen was administered to trypanosome-infected animals. The suppression of the immune response to these antigens did not seem to involve an alteration in the macrophage, as evidenced by a normal uptake and handling of soluble 131I-labeled HSA [human serum albumin] and by a normal immune response when antigen-exposed peritoneal macrophages from trypanosome-infected mice were transferred to normal mice. Probably, T. cruzi induces an immunosuppression to both T-dependent and T-independent antigens, and the depression observed may not be due to an alteration in macrophage function.

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Accession: 006844472

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PMID: 79498

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