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Trypanosoma cruzi induced suppression of the primary immune response in murine cell cultures to thymus derived cell dependent and independent antigens



Trypanosoma cruzi induced suppression of the primary immune response in murine cell cultures to thymus derived cell dependent and independent antigens



Journal of Parasitology 66(1): 16-27



In vitro antisheep erythrocyte (SRBC) and antitrinitrophenyl (TNP) antibody responses of spleen cells obtained from C57BL/6 mice infected with T. cruzi were reduced as early as 6 days postinfection and not detectable after 18 days of infection. Lymph node cells had normal antibody responses to SRBC and TNP in vitro until the 11th day of infection, after which responses were diminished. By day 31 of infection, lymph node cells were unresponsive to both SRBC and TNP in vitro.

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