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Trypanosoma cruzi responses by cells from infected mice to allo antigens



Trypanosoma cruzi responses by cells from infected mice to allo antigens



Experimental Parasitology 51(1): 141-151



In unidirectional mixed lymphocyte cultures containing (as responders, stimulators or regulators) spleen cells from mice infected with T. cruzi, alloantigen responses were less than in cultures containing normal spleen cells only. Depletion of plastic adherent cells from infected spleen cells (stimulators or regulators) reversed their inhibitory effect on normal spleen cells (responders); removal of adherent responder cells and/or B lymphocytes did not alter the low alloantigen responses of normal spleen cells (stimulated by infected spleen cells), or infected spleen cells (stimulated by normal spleen cells). Infected spleen cells were effective in regulating mixed lymphocyte cultures only when added at the initiation of the culture. Serum from infected mice suppressed mixed lymphocyte cultures containing responder spleen cells, syngeneic to the serum donor if added up to 24 h after initiation of cultures; the suppressor serum had to be present at the initiation of cultures when responder cells were allogeneic to the serum donor. Cultures of infected spleen cells (whole or macrophage-enriched) produced a factor which was suppressive when added to mixed lymphocyte cultures containing syngeneic responder cells at initiation. Possibly, the serum suppressor substance regulates cell-mediated immune responses directly by suppressing the response-potential of cells, and indirectly by triggering the release of a factor from adherent splenic cells, which induces a hyporesponsive state in T lymphocytes.

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Accession: 006844534

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PMID: 6450686


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