+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Trypanosoma cruzi responses by cells from infected mice to allo antigens

Trypanosoma cruzi responses by cells from infected mice to allo antigens

Experimental Parasitology 51(1): 141-151

In unidirectional mixed lymphocyte cultures containing (as responders, stimulators or regulators) spleen cells from mice infected with T. cruzi, alloantigen responses were less than in cultures containing normal spleen cells only. Depletion of plastic adherent cells from infected spleen cells (stimulators or regulators) reversed their inhibitory effect on normal spleen cells (responders); removal of adherent responder cells and/or B lymphocytes did not alter the low alloantigen responses of normal spleen cells (stimulated by infected spleen cells), or infected spleen cells (stimulated by normal spleen cells). Infected spleen cells were effective in regulating mixed lymphocyte cultures only when added at the initiation of the culture. Serum from infected mice suppressed mixed lymphocyte cultures containing responder spleen cells, syngeneic to the serum donor if added up to 24 h after initiation of cultures; the suppressor serum had to be present at the initiation of cultures when responder cells were allogeneic to the serum donor. Cultures of infected spleen cells (whole or macrophage-enriched) produced a factor which was suppressive when added to mixed lymphocyte cultures containing syngeneic responder cells at initiation. Possibly, the serum suppressor substance regulates cell-mediated immune responses directly by suppressing the response-potential of cells, and indirectly by triggering the release of a factor from adherent splenic cells, which induces a hyporesponsive state in T lymphocytes.

Please choose payment method:

(PDF emailed within 1 workday: $29.90)

Accession: 006844534

Download citation: RISBibTeXText

PMID: 6450686

Related references

Differences in the regulation of humoral responses between mice infected with trypanosoma cruzi and mice administered trypanosoma cruzi induced suppressor substance. Journal of Immunology 125(5): 2317-2321, 1980

Effects of infection with trypanosoma cruzi on cellular responses to allo antigens. Federation Proceedings 39(3): ABSTRACT 4131, 1980

Macrophage regulation of immune responses of spleen cells from mice infected with Trypanosoma cruzi. Cellular Immunology 138(2): 423-436, 1991

Restoration of in vitro immune responses of spleen cells from mice infected with Trypanosoma cruzi by supernatants containing interleukin 2. Journal of Immunology 133(3): 1570-1575, 1984

Soluble antigens released from trypanosoma cruzi infected fibroblasts are recognized by sera from infected mice. FASEB Journal 5(6): A1703, 1991

Demonstration by immunoelectron microscopy of trypanosoma cruzi antigens specifically labeled with peroxidase in the spleen cells of infected mice subjected to specific chemotherapy. Memorias do Instituto Oswaldo Cruz 82(Suppl. 1): 49, 1987

Spontaneous lytic activity against allogeneic tumor cells and depression of specific cytotoxic responses in mice infected with Trypanosoma cruzi. Journal of Immunology 126(6): 2436-2442, 1981

Circulating antigens from trypanosoma cruzi in experimentally infected mice. Journal of Protozoology 29(2): 332, 1982

Persistence of Trypanosoma cruzi antigens in the inflammatory lesions of chronically infected mice. Transactions of the Royal Society of Tropical Medicine and Hygiene 82(1): 77-83, 1988

Immunoparasitological studies of Trypanosoma cruzi low virulence clones from Panama: Humoral immune responses and antigenic cross-reactions with Trypanosoma rangeli in experimentally infected mice. Scandinavian Journal of Immunology 42(6): 644-650, 1995

Immunology of Chagas' disease I. Circulating antigens in mice experimentally infected with Trypanosoma cruzi. Revista do Instituto de Medicina Tropical de Sao Paulo 18(6): 433-439, 1976

Trypanosoma cruzi: early immune responses in infected mice. Experimental Parasitology 37(3): 417-425, 1975

T cell responses in mice infected and immunized with Trypanosoma cruzi. Memorias do Instituto Oswaldo Cruz 82(Suppl. 1): 336-340, 1987

Contact sensitivity responses in mice infected with Trypanosoma cruzi. Infection and Immunity 22(2): 548-554, 1978

CD8+T cells from mice chronically infected with Trypanosoma cruzi show cytotoxicity against T cruzi amastigote forms by a mechanism mediated by Fas-Fas-L and dependent on IFN-gamma. American Journal of Tropical Medicine & Hygiene 61(3 Suppl. ): 376, 1999