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Trypanosoma cruzi: role of the immune response in the natural resistance of inbred strains of mice



Trypanosoma cruzi: role of the immune response in the natural resistance of inbred strains of mice



Experimental Parasitology 45(2): 160-168



Nine inbred strains of mice were challenged with 104 or 105 trypomastigotes of the Brazil strain of T. cruzi. A resistance spectrum was evident ranging from highly susceptible strains, e.g., C3H, which developed high parasitemias and died within 3-4 wk, to resistant strains, e.g., C57BL/10, which developed low parasitemias and survived. Impairment of the immune system in resistant C57BL/10 mice by X-irradiation, splenectomy or treatment with silica led to high, often fatal parasitemias. Athymic nude mice, in particular, attained exceptionally high parasitemias before drying. The immune response appeared necessary for survival and to play a role in the natural resistance of some mouse strains by effectively eliminating parasites and minimizing parasitemia. Use of congenic strains of mice showed that the principal genetic determinant of resistance was not associated with their H-2 haplotype.

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Accession: 006844539

Download citation: RISBibTeXText

PMID: 210036

DOI: 10.1016/0014-4894(78)90055-3


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